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《Chinese Journal of Emergency Medicine》 2006-01
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Effects of rosiglitazone on pulmonary inflammatory response in endotoxemic rats

LIU Dong, ZENG Bangxiong, ZHANG Shifan, GENG Zhilong, ZHANG Shihai.Department of Anesthesiology, Lanzhou General Hospital, Lanzhou Command of P.L.A., Lanzhou 730050, China  
Objective To investigate the effects of rosiglitazone, an agonist of peroxisome proliferator-activated receptor γ (PPARγ), on acute lung inflammation in endotoxemic rats. Methods Twenty-four male Wistar rats were randomly divided into four groups (n = 6): control group, rosiglitazone (ROSI, 0.3 mg/kg i.v.) group, endotoxin (LPS, 6 mg/kg i.v.) group and ROSI (0.3 mg/kg i.v.) + LPS (6 mg/kg i.v.) group. Four hours after LPS or saline injection, myeloperoxidase (MPO) activity, tumor necrosis factor-α(TNF-α) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) concentrations, and nuclear factor κB (NF-κB) activation were measured in lung tissues. Results Compared with the LPS group, MPO activity, TNF-α and CINC-1 concentrations, and NF-κB activity in the lung tissues were significantly attenuated in the ROSI + LPS group (P 0.01). Conclusion Rosiglitazone could reduce pulmonary inflammation caused by endotoxemia. The anti-inflammatory effect of rosiglitazone may be connected with the inhibition of NF-κB activation.
【Fund】: 解放军全军医学科学技术研究“十五”计划指令性课题项目(01-L003)
【CateGory Index】: R965
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