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《Chinese Journal of Emergency Medicine》 2006-07
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The relationship between oxidative injury and acute renal failure

CHEN Jiaxi HU Ying LIN Li ZHOU Junfu Division of Nephrology,The Second Affiliated Hospital of Zhejiang University College of Medicine,Hangzhou 310009,China  
Objective To study the oxidative injury induced by abnormal free radical reactions in acute renal failure (ARF)patients' bodies.Methods Fifty ARF patients and 50 healthy adult volunteers(HAV)were enrolled in a random control study.The levels of nitric oxide(NO)in plasma,lipoperexide(LPO)in plasma and in erythrocytes,and vitamin C (V_C),vitamin E(V_E)andβ-carotene(β-CAR)in plasma as well as the activities of superexide dismutase(SOD), catalase(CAT)and glutathione peroxidase(GPX)in erythrocytes were determined with speetrophotometrie mothods. Results Compared with the HAV group,the levels of NO in plasma,and LPO in plasma and in erythroeytes in the ARF group were significantly increased(P<0.01),while levels of V_C,V_E andβ-CAR in plasma as well as SOD,CAT and GPX in erythrocytes in the ARF group were significantly decreased(P<0.01 ).Linear correlation analysis showed that with the increase of NO and LPO in plasma and in erythrecytes,and with the decrease of V_C,V_E,β-CAR,SOD,CAT and GPX in the ARF patients,the levels of urea nitrogen and creatinine in serum was gradually increased(P<0.01 ).The discriminatory correct rates of the above biochemical parameters reflecting oxidative damage of the ARF patients were 75.3% to 93%,and the correct rates for the HAV were 70.0% to 91.3% when independent discriminant analysis was used;and the correct rate for the ARF patients was increased to 99.2%,the correct rate for the HAV was increased to 100% when stepwise discriminant analysis was used.The above biochemical parameters' reliability coefficient(alpha)were used to estimate the oxidative damage of the ARF patients as 0.816,the standardized item alpha=0.972,P<0.01. Conclusions A series of free radical chain reactions caused serious pathological aggravation in the ARF bodies,thus resulting in oxidative damage in their bodies.In treating ARF,therefore,it is necessary that suitable dose antioxidants should be supplemented to them so as to alleviate the oxidative damage in their bodies.
【CateGory Index】: R692.5
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