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《Chinese Journal of Emergency Medicine》 2006-11
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Protective effects of lipoxin A_4 on lipopolysaccharide-induced acute lung injury in rats

JIN Sheng-wei,ZHANG Li,YAO Shang-long,WU Ping,YE Du-jun.Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China  
Objective To investigate protective effects of lipoxin A_4 on lipopolysaccharide-induced acute lung injury in rats.Methods Thirty-six male C57BL/6 rats were randomly divided into six groups(n=6):control group,lipoxin A_4(0.1 mg/kg i.v.)group,Zinc protoporphyrin IX(ZnPP,25 mg/kg i.v.)group,endotoxin(LPS,0.3 mg/ml inhalation)group,lipoxin A_4+LPS group and ZnPP+lipoxin A_4+LPS group.At 8 hours after LPS or saline inhalation,white blood cell count,neutrophil count and tumor necrosis factor-α(TNF-α)in bronchoalveolar lavage fluid(BALF)and myeloperoxidase(MPO)activity,the expression and activity of heme oxygenase-1(HO-1)protein in lung tissues were detennined.Results Treatment with lipoxin A_4 decreased the infiltration of neutrophils in the lung tissue,MPO activity and TNF-α concentration,and alleviated the lung injury.However,lipoxin A_4 promoted the expression and activity of HO-1 in the lung tissue.Conclusion Lipoxin A_4 significantly alleviated lipopolysaccharide-induced acute lung injury in mice.
【Fund】: 国家自然科学基金资助项目(30570726 30100226)
【CateGory Index】: R563
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