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《Chinese Journal of Lasers》 2004-06
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Multi-Probe Fiber-Optic Evanescent Wave Biosensorand Its Characterization

HUANG Hui-jie1, ZHAI Jun-hui2, ZHAO Yong-kai1, YANG Rui-fu2REN Bing-qiang1, CHENG Zhao-gu1, DU Long-long1, LU Dun-wu1 1Shanghai Institute of Optics and Fine Mechanics, The Chinese Academy of Sciences, Shanghai 201800, China 2Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China  
A multi-probe fiber-optic evanescent wave biosensor has been developed based on the principle of evanescent wave while light propagates along optical fiber. A laser diode at 635 nm wavelength is used as the light source. The biosensor can interrogate five individual fibers at one time. Thus assays for five separate analytes can be conducted on the same sample. For all the five fibers, sensitivity limit of 0.01 nmol/L is obtained from the detection of Cy5 serial solutions with various concentrations. The response curves of five fibers have good consistency, the relative standard deviation is less than 10%. All the results are comparable with those that are obtained by a commercial biochip scanner. Real-time fluorescence of human IgG binding to goat anti-body IgG antibody immobilized on fiber core has been successfully detected.
【CateGory Index】: TP212.14
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【Citations】
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1 Zhai Junhui 1, Huang Huijie 2, Yang Ruifu *1 , Ren Bingqiang 2, Zhao Yongkai 2 1(Institute of Microbiology and Epidemiology, Beijing 100071) 2(Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800);A Fiber-Optic Evanescent Wave Biosensor for the Specific Detection of Nucleic Acids[J];Chinese Journal of Analytical Chemistry;2003-01
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【Co-citations】
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1 DENG Li-xin, FENG Ying, JIANG Guang-wen, LIU Long, WEI Li-an (College of photoelectric Science and Engineering, National University. of Defense Techn. Changsha 410073, China);Research of Fiber Optic Evanescent Wave Biosensor Based of Correlation Detection[J];Chinese Journal of Sensors and Actuators;2006-03
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【Co-references】
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【Secondary References】
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