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《Journal of Jilin University(Science Edition)》 2009-05
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Preparation of BSA-PLG Microspheres by S/W/O/W Method

XIA Hong-nan,SUN Ya-dong,WANG Xiao-xiao,WANG Jing,FU Yu,SU Zheng-xing,LI You-xin(College of Life Sciences,Jilin University,Changchun 130012,China)  
The BSA-PLG microspheres were prepared by S/W/O/W emulsion solvent evaporation method with biodegradable material PLG607 as the carrier.Drug encapsulation capacity,morphology,particle size characteristics,as well as in-vitro release profiles of the microspheres were discussed.The results show that the microspheres were spherical and smooth and the mean size of the microspheres was 40~70 μm,with a mono dispersibility.The in-vitro release profiles of the microspheres produced from different methods were significantly distinct.With the additives of hydroxypropyl-β-cyclodextrin(HPB) and hydroxyapatite(HAP),the encapsulation of microspheres increased from 27.9% to 46.3%.Therefore,using S/W/O/W method and adding additives HAP and HPB in the formulation could decrease the initial burst release of drugs from the microspheres and increase the encapsulation capacity of the BSA-PLG microspheres,the in-vitro release profiles of which were fitted into near zero order release kinetics.
【Fund】: 吉林大学本科生创新基金(批准号:JDCX2008020)
【CateGory Index】: R944.9
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【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
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