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《Journal of Jilin Agricultural University》 2003-04
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Preparation of Drug Resistance Inhibitors of Escherichia coli

LEI Lian-cheng, HAN Wen-yu, QIAO Hong-wei ( Faculty of Animal Science and Technology, Quartermaster University of PLA , Changchun , Jilin 130062, China ; College of Animal Science and Technology, Xinjiang Agricultural University, Urumqi, Xinjiang 843300, China)  
Twenty-three assumed inhibitors were exacted from traditional Chinese medicine by common practical methods to investigate the effect of reducing drug resistance of 10 multi-drug resistant strains of pathogenic E. coli isolated from clinical samples of human and animal origins. Inhibition effect of assumed inhibitors to drug resistance of all strains were detected by three methods of drilling hole on agar plate, point-planting bacteria on agar plate and testing sensitivity with drug paper. Three effective inhibitors were found in the experiment, inhibitor 1 (IT1) reduced the resistance of E. coli to fluoroquinolone, kanamycin and amphemycin; inhibitor 2 (IT2) and inhibitors (IT3) reduced the resistance of E. coli to fluoroquinolone, gentamycin and deoxycycline, some inhibition rate is up to 90 percent.
【Fund】: 国家自然科学基金资助项目(30170698)
【CateGory Index】: R285
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