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《Journal of Jilin Agricultural University》 2004-03
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Effect of Lentinan on Anti-Exhaustion and Liver Protection of Exhausted Mice

SHI Ya-li~1, XIN Xiao-lin~2, YANG Li-hong~2, CAI De-hua~2 (1.College of Physical Education, Yantai Normal University, Yantai 264025, China; 2.College of Biology, Yantai Normal University, Yantai 264025, China)  
In order to study the effect of lentinan on liver tissues of exhausted mice, an experimental model of exhausting swimming of mice poured lentinan had been established. The method of reagent box was used to measure liver glycogen (LG) at rest, liver MDA, activities of GSH-PX and serum GPT at rest and after exhausting exercise. The results showed that Liver glycogen in resting contrast (RC)group was (36.93±9.81) mg/g, while in resting medicine(RM)group (73.44±21.71) mg/g. Liver glycogen in RM group increased significantly (P0.001). The time of high intensity swimming in EC group was (45.52±7.82) min., while in EM group (49.90±5.31) min. The time of high intensity swimming in EM group prolonged obviously(P0.05). Activity of GSH-PX in RC group was (60.25±(5.31) U/mg), while in RM group (68.37±7.92) U/mg. Activity of GSH-PX in RM group increased obviously (P0.05). Activity of GSH-PX in EC group was (56.77±7.30) U/mg, while in EM group (63.28±(4.23) U/mg.) Activity of GSH-PX in EM group increased obviously (P0.05). Level of MDA in RC group was (5.76±0.87) mmol/L, while in RM group (4.59±0.57) mmol/L. Level of MDA in RM group lowered obviously(P0.05). Level of MDA in EC group was (14.11±1.28) mmol/L , while in EM group (12.53±4.93) mmol/L. Level of MDA in EM group lowered obviously(P0.01). Activity of GPT in RC group was (6.14±1.21) U/L, while in RM group (6.25±1.02) U/L, however there was no significantly difference between them (P0.05). Activity of GPT in EC group was (12.53±(4.93) U/L), while EM group was (7.42±2.90) U/L. Activity of GPT in EM group lowered obviously ((P)0.05). The results showed that lentinan had the obvious effects on anti-fatigue, anti-oxidation and anti-injury, and it could reduce the damage of free radicals after high intensity exhausting exercise.
【Fund】: 山东省科技厅攻关项目(011100108)
【CateGory Index】: R285.5
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