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《Journal of Southern Yangtze University》 2006-01
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The Study of Supercritical CO_2 Extraction of Artemisinin

HU Miao, QIAN Guoping, YANG Yiwen, WU Caijuan, REN Qilong~*(National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University,Hangzhou 310027,China)  
The supercritical fluid extraction(SFE) of artemisinin was studied using ground Artemisia annua L.as raw material and CO_2 as solvent.The effect of operation conditions on the extraction yield was analyzed in a series of experiments at temperatures between 313 and 333 K and pressures between 15.2 and 29.7 MPa and humidity of raw material between 2.5% and(11.3)%.Furthermore,the effect of CO_2 flow rate and particle size of raw material was studied in the range of 0.162 to 1.968 kg/h and 40 to 80 meshes.The optimum conditions were pressure of 20 MPa,temperature of 323 K,a solvent ratio of 1 kg of CO_2 per kg of raw material,and particle size of 60~80 mesh.For high yield of artemisinin,the operating conditions of the separatorⅠ were that the temperature was 323 K and the pressure was 20 MPa.In these conditions,the extraction yield was more than 95% and the purity of artemisinin of the extract was 15% for extraction time of 4 h.
【Fund】: 国家自然科学基金项目(20276058)
【CateGory Index】: TQ461
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