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《Journal of Medical Postgraduates》 2003-05
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The effect of matrix metalloproteinase-9 in acute lung injury following cardiopulmonary bypass

WANG Chang tian, JING Hua, LI Zhong dong, HU Xiao nan, DONG Guo hua, LUO Li guo, GU Wei dong, SHEN Yi, XU Biao, QIAN Jian jun (Department of Cardiothoracic Surgery, Clinical School of Medical College of Nanjing University/Nanjing General Hospital of Nanjing Command, Nanjing 210002,Jiangsu,China)  
Objectives: To study the correlation between plasma matrix metalloproteinase 9(MMP 9) concentration and acute lung injury following cardiopulmonary bypass(CPB). Methods: Human plasma was obtained after informed consent from twenty patients undergoing CPB. Plasma was collected at the beginning of CPB, 5 minutes after the initiation of CPB, at the termination of CPB, 1 hour after the termination of CPB and 6 hours after the termination of CPB. All samples were analyzed by standard enzyme linked immunosorbent assay (ELISA). A aDO 2 and respiratory index (RI) was measured at the termination, 1 hour and 6 hours after termination of CPB. The cross clamp times, CPB times and the time to extubation was recorded. Data were expressed as means ±SE and assessed by analysis of variance (ANOVA).The regression analysis was utilized to define the correlations of variables measured( A aDO 2 ,RI, cross clamp times, CPB times and the time to extubation ) at the end of CPB. Results: Plasma MMP 9 concentration was significantly increased at the end of CPB (430.6±50)μg/L( P 0.01 ) as compared with both the start of CPB(42.6±3.2)μg/L and 5 minutes after the initiation of CPB (97.5±22.8)μg/L. 6 hours after the termination of CPB plasma MMP 9 concentration was close to the concentration of basement level. The correlation between plasma MMP 9 concentration at the end of CPB and cross clamp times was significant. The correlation between lung injury and increased plasma MMP 9 concentration was not significant as we were unable to demonstrate any pulmonary dysfunction in these 20 patients. Conclusions: Patients undergoing CPB showed a significant increase in plasma MMP 9 levels and the effect of cross clamp time was more remarkable.
【CateGory Index】: R654.1
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