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《Journal of Medical Postgraduates》 2005-10
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Experimental studies of formulated Chinese medicinal herbs as a vascular embolizing agent

SHEN Jun-jie~1,CHEN Zi-qian~1,WANG Shu-dong~2,ZHENG Xiao-gang~3,CAO Jian-min~1(1.Department of Medical Imaging;2.Department of Pharmaceutics;3.Department of Pathology,School of Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China)  
Objective: To study the efficacy,safety and relative characteristics of formulated Chinese medicinal herbs as a vascular embolizing agent. Methods: We prepared a mixture as a vascular embolizing agent from several Chinese medicinal herbs,they served as anticarcinogen and/or coagulant according to the Chinese Pharmacopeia.We studied the characteristics of the mixture through embolizing the hepatic artery in eight pigs with it. Results: The mixture was prepared as a suspension.It was easily injected through catheters and showed good histocompatibility and hemo-compatibility without pyrogenetic response and toxicity.The mixture mainly embolized peripheral arteries,maintaining occlusion for 5 weeks and without formation of collateral circulation.We found injuries of normal hepatic tissues as slight hepatocyte hydrops and focal endochyloma necrosis through optical and electronic microscope. Conclusion: This suspended mixture of Chinese medicinal herbs is safe and effective as a potential peripheral embolizing agent.
【CateGory Index】: R285.5;
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