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《Journal of Medical Postgraduates》 2007-02
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The research of pancreatic anlagen transplantation

WANG Lu,HUANG Ya-bing,GUO Hui,ZHU Min,WANG Shu-sen,XIE Lin,ZENG Meng-hua,LI Rong,CHEN Shi (Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)  
Objective:To study the growth and development of embryonic pancreatic anlagen transplantation.Methods: The pancreas from embryonic day(E15.5),E16.5,E17.5 and E18.5 SD rat embryos were implanted into the intra-peritoneal and sub renal capsular site.By 14-21 days after implantation,the graft were resected for investigating,histopathology and immunohistochemistry.Results:①By 21 days after implantation into sub renal capsular site,acinar and ductal tissues were present in E15.5 graft and minimal rejection were observed while moderate rejection were observed of which were implanted into intra peritoneal site.② By 16 days after implantation into sub renal capsular site,E16.5 graft underwent moderate rejection.③ E17.5 and E18.5 graft was severely rejected within 16 days of implantation into sub renal capsular site,neither development nor proliferation ofβcells was present.④By 16 days after implantation into mice's sub renal-capsular site without immunosuppressant,E15.5 graft underwent severe rejection and tissue necrosis.Conclusion:The pancreatic anlagen of appropriated ages could revascularize and grow without immunosuppressant.E15.5 or before is the right embryonic age for transplantation.Contrast to the graft into the intra peritoneal site,the rejection of the anlagen transplanted into the sub-renal capsular site is milder and the latter grows better.
【Fund】: 国家863计划基金资助项目(批准号:2003AA205090)
【CateGory Index】: R657.5
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 SHA Guo-zhu,YIN Guang, JI Da-xi,CHEN Hui-ping, JI Shu-ming, CHEN Jin-song, YIN Li-ping, TANG Zheng,LIU Zhi-hong,LI Lei-shi (Research Institute of Nephrology of PLA, Nanjing General Hospital of Nanjing Command,Nanjing 210002,Jiangsu,China);Immunoadsorption and tacrolimus-mycophenolate-methylprednisolone rescue for accelerated acute rejection in kindeny transplantation[J];Journal of Medical Postgraduates;2004-03
【Co-citations】
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1 CHEN Hao,NIE Hai-bo,HU Wei-lie,ZHU Yun-song,ZHAO Yong-bin,ZHANG Xiao-ming,XIAO Yuan-song(Department of Urology,Guangzhou General Hospital,Guangzhou Military Command Area,Guangzhou 510010,China);Peri-operative protein A immunoadsorption in sensitized renal transplant recipients:a case report and literature review[J];Acta Academiae Medicinae Militaris Tertiae;2006-13
2 WANG Xi-hua, WU Jun, XIE Zhi-jie, YUAN Jun, HE Wei-feng, CHEN Xi-wei, YI Shao-xuan (State Key Laboratory Of Trauma,Burns And Combined Injury, Research Institute Of Burns, Southwester Hospital, the Third Military Medical University, Chongqing 400038,China);Induction of T cell tolerance by transplanting with mixed fetal syngeneic or allogeneic and xenogeneic thymus[J];Journal of Medical Postgraduates;2005-06
3 WANG Yong,JIANG Hui-qing,HONG Zhi-jian,HU Xin-bao,WANG Jun(Department of Plastic Surgery,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Applied anatomy of allograft transplantation with compound tissue of two ears and skin of head and neck[J];Journal of Medical Postgraduates;2006-08
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【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Yuanxin *,Li Ning,Chen Guihua,et al. *Department of Surgery,General Hospital of Nanjing Command of PLA,Nanjing University,Nanjing 210002,China;Combined liver and intestinal transplantation:the first case report in China.[J];Chinese Journal of Practical Surgery;2003-10
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