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《Journal of Medical Postgraduates》 2008-01
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Relationship of nutrition with cancer and its epigenetic DNA methylation mechanism

TENG Li-juan,ZHANG Chang-song reviewing,LI Ke checking(Department of Molecular Epidemiology,Shantou University Medical College,Shantou 515041,Guangdong,China)  
DNA methylation is the best studied of the epigenetic changes that influence the gene expression,and changes in genomic methylation patterns have been observed in many cancer cell lines.Nutrients as methyl donors play essential roles in DNA methylation and may modify cancer risk.This review,with an emphasis on the relationship between nutrition,DNA methylation and cancer,firstly defines methylation with a description of its correlated mechanism,then approaches the molecular mechanism of cancer initiation and development at the methylation level,and lastly summarizes the mechanism underlying the effect of methylation-related nutrients on the process of cancer initiation and development at the molecular level.It also offers some suggestions on cancer prevention at the group nutrition level.
【Fund】: 广东省自然科学基金资助项目(批准号:5300983)
【CateGory Index】: R730.2
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【References】
Chinese Journal Full-text Database 2 Hits
1 FANG Yu reviewing,HU Jian-guo checking(Department of Cardiothoracic Surgery,The Second Xiangya Hospital,Central South University,Changsha 410011,Hunan,China);Methylenetetrahydrofolate reductase gene polymorphism and congenital heart disease[J];Journal of Medical Postgraduates;2009-07
2 FENG An-ning,FAN Xiang-shan reviewing,HUANG Qin,ZHANG Li-hua checking(Department of Pathology,Nanjing Drum Tower Hospital,Nanjing University School of Medicine,Nanjing 210008,Jiangsu,China);Mechanism of SIRT1 acting on tumor formation[J];Journal of Medical Postgraduates;2009-07
【Citations】
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1 Hua-yun Chen, Zhong-ping Chen Department of Neurosurgy/Neuro-oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P.R.China;DNA Methylation and Brain Tumor[J];Chinese Journal of Neuro-Oncology;2005-01
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3 ZHOU Zhi-yi1 reviewing,SHI Qun-li1,WANG Xiu-lai2 checking(1.Department of Pathology;2.Post-doctor's Scientific Research Work Station,Nanjing General Hospital of Nanjing Military Command,PLA,School of Medicine,Nanjing University,Nanjing 210002,Jiangsu,China);Advances in genetics and pathogenesis of primary central nervous system lymphoma[J];Journal of Medical Postgraduates;2007-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 TENG Li-Juan, LI KeDepartment of Molecular Epidemiology, Medical College, Shantou University, Shantou, Guangdong, 515041, P. R. China;Research Progress on the Relationship between Nutrition and Cancer Epigenetics——Histone Modification Mechanisms[J];Chinese Journal of Cancer;2007-09
2 YANG Hong-dan,GAO Shi-yong(Cneter of Research and Development on Life Scineces and Environmental Sciences,Harbin University of Comerce,Harbin 150076,China);Relationship between DNA methylation aberration and human tumor[J];Journal of Harbin University of Commerce(Natural Sciences Edition);2007-04
3 LIU Shuang1,LIN Jing-xian1,LIU Qi1,SHI Qun-li2,WANG Jian-dong2,WU Yuan-zhe1(1.Department of Obstetrics and Gynecology;2.Department of Pathology,School of Clinical Medicine,Southern Medical University/ Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Expression of retinoic acid receptors in human ovarian cancer cell line COC2 treated with Tretinoin[J];Journal of Medical Postgraduates;2007-11
4 CHENG Jing reviewing,SHI Qun-li,ZHOU Xiao-jun checking(Department of Pathology,School of Medicine,Nanjing University / Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Advances in the genetic studies of juvenile granulosa cell tumors[J];Journal of Medical Postgraduates;2008-01
5 ZHOU Shui-gen,1,2,SUN Ying-hao2,WANG Jian-dong3,DONG Ying-chun3,XU Chuan-liang2,GAO Jiang-ping1,ZHOU Xiao-jun3 (1.Department of Urology,the Second Military Medical University,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China;2.Department of Urology,Changhai Hospital,the Second Military Medical University,Shanghai 200433,China;3.Department of Pathology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);EphA1 expression and prostate cancer[J];Journal of Medical Postgraduates;2008-05
6 CHENG Jing,ZHANG Zheng-xiang,SHI Qun-li,ZHAO You-cai,TU Pin,ZHOU Xiao-jun,WANG Xiu-lai(Department of Pathology,School of Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Prognostic factors of primary central nervous system B-cell lymphoma[J];Journal of Medical Postgraduates;2008-11
7 SHEN Qin1,CHEN De-dian2,GAO Qian1,ZHOU Xiao-jun3,WANG Fang1(1.Department of Pathology,Kunming Medical College,Kunming 650031,Yunnan,China;2.Department of Breast Surgery,the Third Affiliated Hospital of Kunming Medical College,Kunming 650118,Yunnan,China;3.Department of Pathology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Pl4ARF and E2F1 suppress human colorectal tumorigenesis[J];Journal of Medical Postgraduates;2009-01
8 WANG Jian-dong1,LI Guo-li2,MA Heng-hui1,WANG Xu-lin2,SHEN Zheng1,RAO Qiu1,PAN Min-hong1,ZHOU Zhi-yi1,DONG Ying-chun1,ZHOU Xiao-jun1(1.Department of Pathology,2.Department of General Surgery,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Expression of receptor tyrosine kinase EphA7 in gastric carcinoma and its clinical significances[J];Journal of Medical Postgraduates;2009-03
9 ZHOU Hang-bo,ZHOU Xiao-jun,MA Heng-hui,LIU Xiao-hong(Department of Pathology,Jinling Hospital,Nanjing 210002,Jiangsu,China);Diagnostic value of clusterin for follicular dendritic cell sarcoma/tumor and anaplastic large cell lymphoma[J];Journal of Medical Postgraduates;2009-06
10 WANG Xu-lin1,LI Guo-li1,WANG Jian-dong2,FAN Chao-gang1,NI Li-deng1,DONG Ying-chun2,LI Ning1,LI Jie-shou1(1.PLA Research Institute of General Surgery;2.Department of Pathology,Nanjing Medical School of Second Military Medical University /Jinling Hospital,Nanjing 210002,Jiangsu,China);Expression of receptor tyrosine kinase EphA1 in gastric cancer and its clinicopathological significance[J];Journal of Medical Postgraduates;2009-07
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 DENG Yu-xia reviewing,SUN Xin-chen checking(Department of Oncology,Zhongda Hospital of Southeast University,Nanjing 210009,Jiangsu,China);Therapeutic drug effects or toxicity depends on genetic polymorphisms in cancer chemotherapy[J];Journal of Medical Postgraduates;2007-03
2 SHEN Wen reviewing,HU Wei-lie checking (Department of Urology,Guangzhou General Hospital of Guangzhou Military Region,PLA,Guangzhou 510010,Guangdong,China);Update of the relationship between the insulin-like growth factor system and primary adrenocortical tumor[J];Journal of Medical Postgraduates;2007-10
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Ji-hong reviewing, YU Ya-ping checking(Department of Hematology, Nanjing General Hospital of Nanjing Military Command,PLA, Nanjing 210002, Jiangsu, China);Recent progress in molecular pathogenesis of B-cell lymphoma[J];Journal of Medical Postgraduates;2005-02
2 SUN Zheng, QI Xiao-ping, XU Zhe, LI Gang, CHEN Che, LI Jie-shou (Research Institute of General Surgery, School of Medicine, Nanjing University; Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China);Effect of Flt-3 ligand on fusion vaccine of dendritic cells and induction of antitumor immunity in vitro[J];Journal of Medical Postgraduates;2006-04
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