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《Journal of Medical Postgraduates》 2012-10
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Effects of electro-acupuncture at different acupoints on restraint stress-induced behavioral changes in rats

SUN Jie1,ZENG Pei-jun1,WEI Hui-fang1,WEN Jin2,ZHONG Da-kui3,LI Ying1,YANG Lei1,ZHANG Lu-fen1(1.College of Acupuncture and Massage,Beijing University of Chinese Medicine,Beijing 100029,China;2.Department of Acupuncture,Mentougou Hospital of Traditional Chinese Medicine,Beijing 102300,China;3.Department of Rehabilitation,Fangshan Hospital of Traditional Chinese Medicine,Beijing 102400,China)  
Objective Clinical observations show that electro-acupuncture has significant effects on stress-induced psychological disorders.This study aims to investigate the effects of electro-acupuncture at different acupoints on restraint stress-induced behavioral changes,and discuss the psychological and behavioral changes caused by immunity disorders and the regulatory effect of electro-acupuncture for these problems.Methods Fifty male Wistar rats were randomly divided into 5 groups(normal,model,Baihui,Guanyuan and Zusanli) of equal number.Apart from those of the normal group,all the other rats were tied into cloth bags for 30 min a day for 20 d to make the restraint stress model.From the 2nd day after modeling,the rats of treatment groups underwent electro-acupuncture for 20 min,once every other day,for 10 times.All the rats were placed in the elevated plus-maze(EPM) for detection of the changes in the number of entries into the open arms(OE) and residence time in the open arms(OT) of EPM before and after modeling,and after the 5th and 10th treatment.Results Compared with the normal rats,the rats of the Baihui group showed significantly decreased OT,while those of the Zusanli group markedly increased number of OEs after the 10th treatment and reduced OT after the 5th(P0.01).In comparison with those of the model group,the number of OEs was significantly increased in the Baihui group(P0.05) but decreased in the Guanyuan group after the 5th treatment,and both OT and OEs remarkably increased in the Zusanli group after the 10th treatment(P0.01).The number of OEs was significantly higher in the Guanyuan group after the 10th treatment(P0.05),and so were OT and OEs in the Zusanli group(P0.01) than after the 5th.Compared with the Baihui group,both the Guanyuan and Zusanli groups exhibited changes in OEs and OT,but with no significant differences(P0.05).Conclusion Electro-acupuncture has some antidepressant and anxiolytic effects by improving emotional and behavioral changes induced by restraint stress.Its antianxiety effect varies at Baihui,Guanyuan and Zusanli,even more obvious at Baihui in the early period of stress,but much more stable and longer at Guanyuan and Zusanli.
【Fund】: 北京市自然科学基金(7052037)
【CateGory Index】: R245.97
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