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《Jilin Medical Journal》 2012-16
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Changes of cytosolic calcium after acute lung injury in neonatal rats

FAN Wei-tang,SUN Xiao-feng(The First Affiliated Hospital Guangzhou University of TCM,Guangzhou 510405,China)  
Objective To explore the role of cytosolic calcium overload in pathogenesis of acute lung injury(ALI) in neonatal rats.Method After endotoxin lipopolysaccharide(LPS) induced acute lung injury(ALI) in neonatal rats,concentrations of calcium in alveolar epithelial cells were determined.Results After treatment with LPS,concentration of calcium in alveolar epithelial cells increased gradually.The value at 2 hours significantly increased than that of the control group(P0.05).Then it reached peak at 8 hours and decreased in the following.Conclusion Cytosolic calcium overload maybe the important mechanism for the necrosis of alveolar epithelial cell in acute lung injury.
【CateGory Index】: R563.8
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