The Effects of Some Free Radical Scavengers on Ouabain—induced Arrhythmias in Guinea Pigs——Free Radicals May be Involved in the Toxicity of Digitalis
Huang Renbiao Tutor: Prof. Lo Qian (Lo Sing) (Dept. of Pharmacology)
The effects of some free radical scavengers on the cardiotoxicity of digitalis with the model of ouabain-induced arrhythmias in urethane-anethetized guinea pigs were studied The doses of ouabain to produce ventricular premature beats(VP), ventricular fibrillation (VF) and cardiac arrest(CA) were taken as indicators, of measuring the cardiotoxicity of digitalis. The results showed that GSH, the purified saponin Rg_1, Rb_1 of Panax notoginseng and AA had protection for ouabain-induced arrhythmias in varying degrees and decreased the cardiotoxicity of digitalis. These suggest that free radicals may be involved in the toxicity of digitalis.