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Biological effects of basic fibroblast growth factor on bone marrow stromal cells

ZHENG Lei;WANG Qian (Dept.of Medical Examination, Nanfang Hospital, The First Mi litary Medical University, Guangzhou 510515, China)  
Aim: To investigate the biological effects of basic fibroblast gr owth factor(bFGF) on the cell adhension, proliferation and differentiation of bo ne marrow stromal cells(BMSC). Methods: After induction of different concentrati ons of bFGF, calculate the attached cells with stereological method, measure cel l proliferation with MTT method and cell differentiation with ALP measurement ki Results: 10 ng/mL bFGF can promote cell adhension significantly, while 200 ng/mL bFGF may inhibit cell attachement; we also found that 100 ng/mL bFGF can promote cell proliferation significantly, however ALP was the lowest. Conclusion: bFGF may play compound and multiple roles in the biological effect of BMSC, including cell adhension, proliferation and differentiation. This effect is connected with the concentration of bFGF
【CateGory Index】: R318
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