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《Journal of Jinan University(Natural Science & Medicine Edition)》 2005-06
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Changes of basic fibroblast growth factor in periodontal tissue during orthodontic tooth movement in young rat

TANG Xin-bao~1,LIU Jing~2(1.Department of Orthodontia,Hospital of Stomatology of Changsha,Changsha 410005,China;2.Department of Stomatology,Medical College,Jinan University,Guangzhou 510632,China)  
Aim: To research on the distribution and changes of basic fibroblast growth factors(b-FGF) in periodontal tissue by establishing orthodontic tooth movement model of young Wistar rats and to analyze the role of b-FGF in orthodontic tooth movement.Methods: The orthodontic tooth movement model in young Wistar rats was established.The rats in experimental group or control group in different period of time were quickly perfused through arterial aorta with 4% neutral formaldehyde.Then,the first molar and periodontal tissues were taken out,decalcified and manufactured to form paraffin sections.The distribution and changes of b-FGF in the periodontal tissues of the first molar were observed by SP immunohistochemisical technigue. The integrated grey(IG) of b-FGF was analyzed by Mias-2000 image analyzer and statistical analysis was performed by SPSS10.0 statistical package.Results: There was low expression of b-FGF in the periodontal tissues of normal rats.The expression of b-FGF in the cementoblast on the tension side was higher at the first day in experimental group than that in control group.Compared with control group and tensional side group,the b-FGF expression in the fibroblast and osteoblast was stronger at the 10th and 14th day in experimental group.Conclusion: These results indicate that b-FGF participates in the periodontal tissue remodeling during orthodontic tooth movement.
【CateGory Index】: R783.5
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