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《Journal of Jinan University(Medicine Edition)》 2007-04
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The ultrastructural effects of the heart cells of the fetus of rats with streptozotocin-induced gestational diabetes mellitus rats

LIU Guo-sheng1,LUO Yao1,ZHAO Li-hua1,LIU Hai-ying1,KANG Ju-ling2,TANG Fu-xing3,TANG Hai-lan3,GUO Zhu-wen3(1.Department of pediatrics;2.Department of pathology;3.Department of electron microscope,First Affiliated Hospital,Jinan University,Guangzhou 510632,China)  
Aim:To explore the mechanism of abnormal ultrastructural change of the heart tissues in fetus of diabetic mother(IDM),the ultrastructural changes of heart tissues in infant of streptozotocin-induced diabetic pregnant rats are studied. Methods:The SD pregnant rats were divided into two groups randomly.One was GDM group(n=27).All rats were injected STZ or PBS respectively at abdominal cavity.Blood glucose,urine glucose and body weight every day were observed,after 72 h when rats were given STZ or PBS,all rats were uterine-incision delived to obtain the materials from embryo heart tissues at gestation 13th,16th,19th day randomly to observe the ultrastructure of the heart tissues.Results:In the embryo rats' heart of DM group,the pathological change of cardiocyte ultrastructure at different extent could be seen:the cell-cell junction is less,the width is different,the muscle bundle arranges irregularly,and the cell membrane was not integrate.The electron density of cytoplasm was higher,the mito chondria became swelling even balloon degeneration,the crista was less,the rough endoplasmic reticulum(RER) became decrease and dilate,there was some small fatty substance.The size and shape of nucleus was different,like irregular spherical,nuclear membrane structure was ambiguity,the disposition of chromatin was uneven,and there was some abnormal chromatin.The collagen fiber of extracellular substratum arraies fasc,there was akaryocyte in the outer of capillary lumen and some chip organelle.Conclusion:Streptozotocin-induced gestational diabetes mellitus may cause abnormal change of ultrastructure in the heart tissues,which may be pathological foundation of cardiac anomalies of IDM.
【Fund】: 广东省科技计划项目(2004B30701009)
【CateGory Index】: R714.2
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