Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Jinan University(Medicine Edition)》 2008-04
Add to Favorite Get Latest Update

Role of CREB in curcumin improve learning and memory dysfunction in rats induced by gp120

HUANG Tao1,2,3,DONG Jun1,2,3,LU Da-xiang1,2,3,TANG Hong-mei1,2,3,PAN Rui4,FU Yong-mei1,2,3(1.Department of Pathophysiology,Medical College;2.The Key Laboratory of National Administration of Traditional Chinese Medicine;3.Institute of Brain Research,Jinan University,Guangzhou 510632,China;4.Department of Orthopaedics,the First Affiliated Hospital,Jinan University,Guangzhou 510630,China)  
Aim:To investigate the role of CREB in curcumin improve learning and memory dysfunction in rats induced by gp120.Methods: The SD rats were divided into six groups: control group,sham group,model group,low dose curcumin group,middle dose curcumin group and high dose curcumin group.Except control and sham group,the others four groups received slowly 5 μL/d gp120 which dissolved in artificial cerebrospinal fluid(ACSF) for 3 days.From the fourth day,the rats of low,middle,high dose curcumin groups were treated with 50,100,200 mg/kg curcumin every day,respectively.The others groups were treated with redistilled water.The treatment will last for 14 days.Subsequently,the water maze test and pCREB immunohistochemical staining in hippocampus were applied to evaluate the effect of curcumin on the rats.Results: ① Space probe test showed that the rats in model group had a bit clumsy and spent a significantly longer time to seek the target quadrant,and that the rats in model group had the shorter retention time and less frequency of accrossing target quadrant compared with those in control group(P0.05).However,the rats in low,middle,high dose curcumin groups spent a significantly shorter time to seek the target quadrant and had the longer retention time and more frequency of accrossing target quadrant compared with those in model group(P0.05),and low dose curcumin group was better than the other two groups(P0.05).② Immunohistochemical staining showed that the expressions of pCREB in model group decreased compared with the control groups(P0.01),while the expressions of pCREB in low、middle and high dose curcumin groups increased compared with the model groups.Conclusion:The mechanism of curcumin improving learning and memory dysfunction induced by gp120 maybe related with upregulated the expression of phosphorylated CREB.
【Fund】: 广东省自然科学基金项目(06105246);; 广东省医学科研课题项目(A2006334);; 广州市科技计划项目(2007J1-C0041);; 国家中医药管理局病理生理学重点实验室开发放基金项目(51206011 51207029)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Xiao-yan 1, DONG Jun 1, LU Da-xiang 1, FU Yong-mei 1, PAN San-qiang 2, YANG Chang-shan 3 (? 1?Department of Pathophysiology,? 2?Department of Anatomy, Medical College of Jinan University, Guangzhou 510632, China;? 3?Department of Pathophysiology, Guangzhou Medical College, Guangzhou 510182, China);Effects of Chinese medicine SMⅠon learning and memory ability and hippocampal BDNF expression in mice with Alzheimer's disease[J];Chinese Journal of Pathophysiology;2005-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 AN Lan - min1, YANG Jun1,XU Bing2(1.Health and anti-epidemic station of Shijiazhuang, Shijiazhuang, 050011 China; 2.Hebei Medical University,shijiazhuang 050011, China);STUDIES ON THE APOPTOSIS AND THE EXPRESSION OF p53 BY LEAD IN RAT BRAIN[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-04
2 AN Lan-min1 ,NIU Yu-jie2 ,XU Bing2,LIU Na1 (1. Health and Anti-epidemic Station of Shijiazhuang,Shiijazhuang,050011,Hebei,china;2.Hebei Medical University,Shiiazhuang,050011 Hebei,China);Influence of Lead on the Apoptosis and the Expression of fos,jun,p53 and Nitric Oxide Synthase in Rat Brain[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
3 YANG Yong-xing,XU Guan-sun,SHEN De-kai,ZHU Qing-feng,LIU Yong,ZHANG Dao-qin (Institute of Acupuncture and Meridians,Anhui College of TCM,Anhui Hefei 230038,China);MAGNIFYING EFFECT OF MICRO-INJECTION OF VASOACTIVE INTESTINAL PEPTIDE INTO DORSAL MOTOR NUCLEUS OF VAGUS COMPLEX ON GASTRIC MUCOSA BLOOD FLOW AND MODULATIONEFFECT OF ELECTRIC ACUPUNCTURE IN RATS[J];Journal of Anhui Traditional Chinese Medical College;2001-04
4 ZHU Qing feng tutor:XU Guan sun, SONG Xiao ge (Institute of Acupuncture & Meridians, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038,China);EFFECT OF ELECTRO ACUPUNCTURE ON MOTILIN LEVEL IN BRAIN AND BLOOD OF MORPHINE WITHDRAWAL RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-01
5 HE Feng Tutor:YANG Jun, XU Guan sun, SHEN De kai (Second Clinic Department, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038, China);INFLUENCE OF ELECTROACUPUNCTURE ON LEARNING AND MEMORY FUNCTION AND CEREBRAL BLOOD FLOW IN VASCULAR DEMENTIA RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-03
6 YIN Wei-ping 1, JIANG Ying 1, JIANG Ju-xiang 2, WANG Wei-ping 2 (1 Medical College, Suzhou University, Suzhou,215007; 2 College of Life Science, Suzhou University);Changes of Free Amino Acid Levels in Different Brain Regions of Aging Rats[J];Amino Acids & Biotic Resources;2001-04
7 WANG Wei-ping,JIANG Ju-xiang,JIANG Ying,XU Ying (Department of Biochemistry,Suzhou University,Suzhou 215007);Analysis of Polyamine Level in Certain Brain Regions of Aging Rats[J];Amino Acids & Biotic Resources;2002-01
8 WANG Bing-gao, YUAN Xin-yan, WANG Shou-biao, et al (Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, China);;AN IMPROVEMENT OF THE MODEL OF FOCAL CEREBRAL ISCHEMIA AND REPERFUSION WITH LINE OCCLUSSION IN RATS[J];Acta Acadimae Qingdao Umvesitatis;2005-01
9 Guo Hui, Chi Huanfang, Wang Shoubiao, et al Department of Anatomy, Qingdao Medical College, Qingdao 266021;OBSERVATION OF NERVE FIBER CONNECTIONS BETWEEN LOCUS COERULEUS AND DORSAL COLUMN NUCLEI IN RATS[J];;1997-01
10 HUANG Hua HE Hai Yan HUANG Yi hua YU Hui WEI Wei SUN Jiu Rong (College of Life Science, Peking University, Beijing 100871, China);Influence of transsection of fimbria-fornix on the recovery of locomotive equilibrium ability after traumatic brain injury in rats[J];Acta Zoologica Sinica;2003-02
China Proceedings of conference Full-text Database 1 Hits
1 Huang Lili Li Tingli Guo Lengqiu Sun Chunyu (Heilongjiang University of Traditional Chinese Medicine,Harbin 150040);The effects of Schisandra Fruit on the sleep of freely moving rats[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Xiao-yan,DONG Jun,LU Da-xiang,YANG Chang-shan (Dept. of Pathophysiology, Medical College, Jinan University, Guangzhou 510632, China);Effect of traditional Chinese medicine compound SMⅠ on function of learning and memory in memory disorder mice[J];Journal of Jinan University(Natural Science & Medicine Edition);2004-02
2 LUO Huan Min *, XIAO Fei (Neuropharmacological Research Laboratory, College of Pharmacy, Jinan University, Guangzhou 510632, China);Alzheimer-like pathological changes of mice induced by D-galactose and aluminum trichloride[J];Chinese Journal of Pharmacology and Toxicology;2004-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved