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《Journal of Jinan University(Natural Science & Medicine Edition)》 2010-02
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The effect of Shenfu injection as adjunctive therapy in patients with severe head injury

HUANG Yang-xiao1,LU Jie-yun1,LU Yu-zhen1,XU Dian-shuang2,LI Wei2(1.Department of Neurosurgery,Dong Keng Hospital,Dongguan 523451,China;2.Department of Neurosurgery,the Frist Affiliated Hostipal,Jinan University,Guangzhou 510630,China)  
Aim:To discuss the brain protection of Shenfu injection in the patients with severe head injury.Methods: Seventy-two patients were randomly divided into two groups.In the controlled group,patients had received the routine therapy,whereas patients in the Shenfu group took the routine therapy and Shenfu Injection with dose 1 mL/kg,tid for 10 days.All patients were monitored for the intracranial pressure(ICP).The highest ICP,days of coma,dosage and days of using mannitol,complications,and prognosis in comparing between the two groups.Results: The mean value of the highest ICP were(22±12)mmHg and(26±9)mmHg in the Shenfu group and the controlled group respectively.Patients in Shenfu group used mannitol for(6±3)d,comparing to(7±5)d in controlled group.Mean duration of coma in patients of Shenfu group was(9±4)d,comparing to(11±4)d in Controled group.There were significant differences in all parameters above(P0.05).Conclusion: Shenfu injection has a certain protective effect on the severe head injury.
【Fund】: 广东省医学科研基金项目(A2008353)
【CateGory Index】: R651.15
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