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《Journal of Jining Medical College》 2008-01
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Effects of Rosiglitazone and Metformin on Insulin Resistance and Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus

LIU Yanqing,WANG Xuguang(Shangdong Academy of Medical Sciences)  
Objective To analyze the relationship between insulin resistance,FINc and carotid intima-media thickness in type 2 diabetes mellitus,and to observe the therapetic effects of rosiglitazone and metformin,and investigate the potential cardiovascular protective effect of thiazolidinediones and biguanides and the early atherogenic risk factors in patients with type 2 diabetes mellitus.Methods 141 subjects with type 2 diabetes mellitus were selected and divided randomly into three groups: rosiglitazone,metformin and alliance groups,then the three groups were given different medicine.For 12 weeks,then compared the changes of above indexes with treatment.Results After treatment FINs and IRI of alliance group were showed more a decrease than rosiglitazone group(P0.05) and metformin group(P0.000).three groups before and after treatment the level of CIMT were not showed a significantly decrease(P0.05).Conclusion Resiglitazone and metformin may reduce more fasting insulin and insulin resistance than dependent each one,but three medicine have no influence on CIMT in short time.
【CateGory Index】: R587.1
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【Co-citations】
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