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《Progress of Anatomical Sciences》 2010-01
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The protection effect of acupuncture of baihui and dazhui points on the dopaminergic neurons in PD mice

WANG Yuan-yuan,SUN Hong-mei,HE Xin,WU Hai-xia,XU Hong,GAO Yu-shan,WANG Zhi-yong,BAI Li-min(Department of Anatomy,Beijing University of Chinese Medicine,Beijing 100029 China)  
Objective To study the protection effect of acupuncture of Baihui and Dazhui points on the dopaminergic neurons in Parkinson's disease(PD) mice and explore the possible mechanism of acupuncture in treating Parkinson's disease.Methods Thirty male C57BL/6 mice were randomly divided into five groups:normal control group,model group(PD model was made by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP),acupuncture group,Medopa group,acupuncture mixed with Medopa group(six mice for each group).The animals were killed on the 14th day after first injectiion of MPTP.The changes of behavior of rats were detected by climbing rod method.The levels of forebrain monoamines neurotransmitters were measured by high pressure liquid chromatograph.The TH+(Tyrosine hydroxylase) dopaminergic neurons in the substantia nigra were counted in every group by immunohistochemistry technique.Results The time of climbing rod was shorter in acupuncture group and acupuncture mixed with Medopa group(P 0.05) than in model group.Compared with normal control group,the levels of dopamine(DA)、dihydroxv-phenyl acetic acid(DOPAC) were lower in all other groups(P0.05).Meanwhile,the number of TH+ positive neurons was less in model group than in normal group,and also less in 3 treatment groups than in normal group,but more in 3 treatment groups than in model group.Conclusions Acupuncture of Baihui and Dazhui points can improve PD mice's behavior disorders,which is probably related to reducing the dopaminergic neurons missing.
【Fund】: 北京自然科学基金资助项目(No.7083109)
【CateGory Index】: R245
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