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《Progress of Anatomical Sciences》 2015-01
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The effect of zinc on the expression of substance P in dorsal root ganglian and the thermal pain threshold in capsaicin-induced neuropathic pain mice

ZHANG Xiao-jie;LIU Xiao-lu;LI Fu-xing;HAN Yan-xiu;WANG Yue-jing;ZHANG Li;Department of General Surgery, Jinzhou Chinese Medicine Hospital;Department of Histology and Embryology,Liaoning Medical College;  
Objective To study the effect of zinc on the expression of substance P(SP) in dorsal root ganglian and the thermal pain threshold of capsaicin-induced neuropathic pain(NPP) in mice.Methods 48 C57/BL6 mice were divided into 4 groups randomly,then capsaicin was injected in the right hind foot of mice to build the NPP mice model.Mice in control group and N-NPP group were fed by normal food,in L-NPP group fed by low-zinc food,in H-NPP group fed by high-zinc food.Then the control group were injected with solvent(Tween 80,alcohol and saline),while the other group were injected with capsaicin 2 weeks later.Autometallography,thermal pain threshold observation,immunohistochemistry and image analysis were used to examine the effect of zinc on the expression of SP in dorsal root ganglian and the thermal pain threshold at the 7th day after injection.Results High-zinc feed can increase zinc level in dorsal root ganglian and the thermal pain threshold,downregulate the SP expression level(P 0.01).Low-zinc feed can reduce the zinc level in dorsal root ganglian and the thermal pain threshold,upregulate the SP expression level(P 0.01).Conclusion Zinc can inhibit the SP expression in dorsal root ganglion and improve the thermal pain threshold in capsaicin-induced NPP model mice.
【Fund】: 辽宁省科技计划项目(No.2013225305);; 辽宁省大学生创新训练计划项目(201210160007);; 辽宁医学院横向基金(LYHX2013025 2013024);; 奥鸿博泽研究生科研创新基金(2012009)
【CateGory Index】: R741;R-332
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