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《Acta Anatomica Sinica》 2002-06
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In situ HYBRIZATION STUDY ON GAP-43mRNA EXPRESSION DURING NERVE INJURE

LIU Guang\|jiu, LI Zhen\|qiang, YIN Yu\|qin * ,SONG Lin, SUN Jian\|sen (Department of Anatomy, the Third Military Medical University,Chongqing 400038,China) [  
Objective To study GAP\|43mRNA expression during nerve injure and regeneration. Methods Rat sciatic nerve was crushed then, in situ hybridization technique was used to explore GAP\|43mRNA expressions in spinal cord and dorsal root ganglion (DRG). Results The neurons of spinal cord and DRG were detected to have GAP\|43 hybridization sinal by 2 days after sciatic nerve lesion. At later times(4,7 and 14 days postsurgery) the anterior horn motor neurons and DRG cells showed an increase in the number of GAP\|43mRNA positive neurons, followed by a significant rise in their content of GAP\|43mRNA. The number of GAP\|43mRNA positive neurons was decreased by 30 days postinjure, and was nearly nomal 60 days postinjure.Conclusion GAP\|43mRNA expression was increased during peripheral nerve injure and regeneration. The study showed that GAP\|43 may play a key role in nerve regeneration. [
【Fund】: 国家自然科学基金资助项目 (3 95 70 3 73 )
【CateGory Index】: R346
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