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《Acta Anatomica Sinica》 2007-02
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GANODERMA SPORES REDUCING THE OCCURRENCE OF EMBRYONIC NEURAL TUBE DEFECTS INDUCED BY RETINOIC ACID IN PREGNANT MICE

XIONG Yi,ZENG Yuan-shan~(*),ZHANG Wei,CHEN Sui-jun,ZHONG Zhi-qiang(Division of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou510080,China)  
Objective To explore whether ganoderma spores could help the neural epithelial cell of embryonic neural tube stagnated by retinoic acid in G-0/G-1 phase reenter the cell cycle,keep on proliferating and differentiating,and could reduce the occurrence of neural tube defects(NTDs). Methods When E7.75d,mice of the control group and the ganoderma spores group were given intragastrically onetime retinoic acid all-trans.Then the ganoderma spores solution was given intragastrically to the ganoderma spores group.At E10.5d,The embryos of the two groups were taken out and the ratio of NTDs was counted respectively Immunofluorescence histochemistry and flow cytometry were applied to examine the expression of nestin,and DNA quantity staining and RT-PCR to detect the mRNA transcriptions of Cdk2 and Cdk4. Results The radio of NTDs in the ganoderma spores group was lower than that in the control group remarkably,but the level of nestin was higher.With the neural tube cell cycles compared the cell radio of G-0/G-1 phase in the control group was higher than that in the ganoderma spores group,while the ratio in the S phase in the control group,it was lower than that of the normal embryos in the ganoderma spores group.The neural epithelial cell of embryonic neural tube in the ganoderma spores group could transcript Cdk4 mRNA normally,with a low transcription rate in the control group.Conclusion Ganoderma spores can reduce the occurrence of embryonic NTDs induced by retinoic acid in pregnant mice.
【Key Words】: Ganoderma spores Retinoic acid Neural tube defects Nestin Cyclin dependent protein kinase Embryo Mouse
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 LI Hong li, CAI Wen qin, YANG Zhong, LI Ze gui, LI Wei, FU Xiao lan (Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China);Changes of the neural stem cells in the retinoic acid induced neural tube defect in mice[J];Acta Academiae Medicinae Militaris Tertiae;2003-01
2 ;灵芝的抗肿瘤作用机制[J];BASIC MEDICAL SCIENCES AND CLINICS;2000-05
3 ZHANG Wei,ZENG Yuan-san~*,CHEN Sui-junDivision of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou 510080,China;EFFECTS OF GANODERMA SPORE ON SURVIVAL AND EXPRESSION OF NT-3 AND NOS OF SPINAL MOTOR NEURON FOLLOWING VENTRAL ROOT CUT IN THE RAT[J];Acta Anatomica Sinica;2005-05
4 MA Qin-tao,ZENG Yuan-san~(*),ZHANG Wei,CHEN Sui-jun(Division of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-Sen University,Guangzhou 510080,China);EFFECTS OF GANODERMA SPORE AND L-NNA ON THE NEURONAL SURVIVAL AND AXONAL REGENERATION IN CLARKE'S NUCLEUS AND RED NUCLEUS AFTER RAT SPINAL CORD INJURY[J];Acta Anatomica Sinica;2005-06
5 Wei ZHANG~(1),Yuan-Shan ZENG~(1),Yang WANG~(2),Wei LIU~(2),Jin-Jun CHENG~(1),Sui-Jun CHEN~(1)(1.Division of Neuroscience,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou,Guangdong Province 510080,China;2.Proteome Laboratory,Zhongshan Medical College,Sun Yat-sen University,Guangzhou,Guangdong Province 510080,China);Primary study on proteomics about ganoderma lucidium spores promoting survival and axon regeneration of injured spinal motor neurons in rats[J];Journal of Chinese Integrative Medicine;2006-03
6 DAI Li,ZHU Jun, ZHOU Guangxuan, WANG Yanping, WU Yanqiao, MIAO Lei, LIANG Juan National Center for Birth Defects Monitoring, The Second West China Hospital, Sichuan University, Chengdu 610041, China;Dynamic monitoring of neural tube defects in China during 1996 to 2000[J];Chinese Journal of Preventive Medicine;2002-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HUANG Shu-ming~(1,4),YANG Xin-lin~1,HUANG Jian~1,WU Jian-hua~1, XU Jian-lan~3,ZHU He-sun~2 (1.School of Life Science and Technology, Beijing Institute of Technology, Beijing100081, China; 2.School of Material Science and Engineering, Beijing Institute of Technology, Beijing100081, China; 3.Sanlian Hi-Tech Limited Company, Wuxi, Jiangsu214023, China; 4.Bengbu Technological Academy, Bengbu, Anhui233030, China);HPLC Fingerprinting of Triterpenoids from Ganoderma Lucidum[J];Journal of Beijing Institute of Technology;2004-05
2 LIN Zhi-bin△, WANG Peng-yun(Department of Pharmacology, Peking University School of Basic Medical Sciences, Beijing 100083, China);The pharmacological study of Ganoderma spores and their active components[J];Journal of Peking University(Health Sciences);2006-05
3 WEI Yong, YING Da jun, ZHU Chu hong, ZHANG Wei, DONG Shi wu (Department of Anatomy, College of Basic Medicine, Third Military Medical University, Chongqing 400038, China);Isolation and identification of retinal stem cells in mouse eye[J];Acta Academiae Medicinae Militaris Tertiae;2003-24
4 QIU Xiao qiang,SHEN Li ping,ZENG Xiao yun,TANG Zheng hua, ZHANG Zhi yong.(Department of Epidemiology,Public Heath College of Guangxi Medical University,Nanning,Guangxi 530021, China);Case-control studies of nerual tube defects in Guangxi province's seven cities[J];Chinese Journal of Child Health Care;2004-01
5 ZHANG Wei, ZENG Yuan,shan, XIONG Yi, TANG Jiu,yu, CHEN Sui,jun, ZHONG Zhi,qiang. Division of Neurosciences, Department of Histology and Embryology, the Zhongshan School of Medicine, Sun Yat,sen University, Guangzhou 510080 China;Effects of ganoderma spores on CDK4 expression in preventing embryonic neural tube defects induced by retinoic acid in pregnant mice[J];Anatomy Research;2006-04
6 CHEN Sui-jun,ZENG Yuan-shan,ZHANG Hui-jun,ZHANG Wei,DING Ying,ZHONG Zhi-qiang.Division of Neuroscience,Department of Histology and Embryology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080 China;Effects of combination of the ganoderma spore oil and deep sea fish oil on learning and memory ability and NOS expression of hippocampal neuron in mouse[J];Anatomy Research;2007-01
7 ZHOU Wen,ZENG Yuan-shan,ZHANG Wei,CHEN Qiao-ge,CHEN Sui-jun.Division of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou 510080 China;Effects of panax notoginsenosides on neuronal survival in dorsal nucleus of Clarke and red nucleus in injured spinal cord of rat[J];Anatomy Research;2007-02
8 Chen Yanchun1,Guan Yingjun1, Liu Huancai2, Yu Li1 ,Zhao Chunyan1(1Department of Histology and Embryology,Weifang Medical College;2Affiliated Hospital of Weifang Medical College, Shandong 261042,China);INFLUENCE OF CYCLOPHOSPHAMIDE ON THE DIFFERENTIATION OF RAT NEUROEPITHELIAL CELLS INTO NEURONS[J];Chinese Journal of Histochemistry and Cytochemistry;2009-01
9 He Le1,Yang Junjie1,Peng Yuli1,Wang Jingpeng1,Qin Maolin2,Li Hongli2(17th Student Team,2 Department of Histology and Embryology,Department of Developmental Biology,Chongqing Institute of Neuroscience,College of Basic Medical Sciences,Third Military Medical University,Chongqing,400038,China);Vinyl chlorid induces embryo neural tube defect in mice[J];Acta Academiae Medicinae Militaris Tertiae;2010-02
10 ZHU Jin-li1,DING Hui2,GAO Rui-hong1,DONG Ou1,LIU Guang-mei1,FAN Hang1.(1 Daxing District Maternal and Child Health Care Center,Beijing 102600,China;2 Beijing Maternal and Child Health Care Hospital,Beijing 100026,China);Monitoring of birth defect in Beijing Daxing district from 1997 to 2008[J];Chinese Journal of Child Health Care;2010-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Ma Qintao, Zeng Yuanshan~*, Zhang Wei, Chen Suijun(Division of Neurosciences, Department of Histology and Embryology, Zhongshan Medical College,Sun Yat-sen University Guangzhou 510080, China) \;;EFFECTS OF GANODERMA SPORES AND L-NNA ON ACTIVITY OF MITOCHONDRIAL CYTOCHROME OXIDASE IN CLARKE’S NUCLEUS AFTER SPINAL CORD INJURY[J];Chinese Journal of Histochemistry and Cytochemistry;2005-04
2 ZHANG Yan qing,ZENG Yuan shan * ,WU Li zhi,LI Hai biao,CHEN Sui jun (Division of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat sen University,Guangzhou\ 510080,China);EFFECTS OF SCHWANN CELLS ON THE NEURONAL SURVIVAL AND EXPRESSION OF NITRIC OXIDE SYNTHASE IN CLARKE’S NUCLEUS AFTER SPINAL CORD HEMISECTION IN RAT[J];Acta Anatomica Sinica;2003-01
3 CHEN Qian, ZENG Yuan-shan * , CHANG Wei, CHEN Sui-jun(Division of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou\ 510080,China);EFFECTS OF SCHWANN CELLS AND L-NNA ON THE NEURONALSURVIVAL IN RED NUCLEUS OF BRAIN STEM AFTERSPINAL CORD HEMISECTION IN RAT[J];Acta Anatomica Sinica;2004-05
4 ZHANG Wei,ZENG Yuan-san~*,CHEN Sui-junDivision of Neurosciences,Department of Histology and Embryology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou 510080,China;EFFECTS OF GANODERMA SPORE ON SURVIVAL AND EXPRESSION OF NT-3 AND NOS OF SPINAL MOTOR NEURON FOLLOWING VENTRAL ROOT CUT IN THE RAT[J];Acta Anatomica Sinica;2005-05
5 HU Ying Hui, LIN Zhi Bin, HE Yun Qing 1, ZHAO Chang Jia 1 (Department of Pharmacology, School of Basic Medical Sciences, 1Traditional Medicine Laboratory, School of Pharmacy, Beijing Medical University, Beijing 100083);Polysaccharides isolated from mycelia of Ganoderma lucidum induced on HL 60 cell apoptosis by enhancing macrophage activity[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-01
6 Hu Yinghui(Hu YH) and Lin Zhibin(Lin ZB) (Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University, Beijing 100083);EFFECTS OF POLYSACCHARIDES ISOLATED FROM MYCELIA OF GANODERMA LUCIDUM ON HL60 CELL APOPTOSIS[J];ACTA PHARMACEUTICA SINICA;1999-04
7 ;Observation on Antianoxia Function of Magic Fungus-glossy ganoderma Spore Powder[J];Yunan Journal of Traditional Chinese Medicine and Materia Medica;2002-06
8 Fang Yousheng, Chen Desong, Gu Yudong. Department of Hand Surgery, Huashan Hospital, Shanghai Medical University,Shanghai 200040;Facilitated regeneration of rat peripheral nerves with mixture of dangshen,astragalus root,red sage root,et al[J];CHINSES JOURNAL OF HAND SURGERY;1998-03
9 ZHANG Feng, GU Yudong, XU Jianguang, et al Department of Hand Surgery, Hua Shan Hospital, Shanghai Mediacal University, 200040 China;Effect of extract of leave Ginkgo Biloba on crushed sciatic nerve regeneration[J];Chinese Journal of Microsurgery;2000-04
10 Wang Yanping, Zhu Jun, Wu Yanqiao, et al. National Center for Birth Defects Monitoring West China University of Medical Sciences, Chengdu 610041;Dynamic Variation of Incidence of Neural Tube Defects during 1988 to 1992 in China[J];CHINESE JOURNAL OF PREVENTIVE MEDICINE;1998-06
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