EXPRESSION OF Bcl-2 AND Bax PROTEINS IN THE DEVELOPING SMALL INTESTINE OF HUMAN FETUS
LIU Xue-hong 1 , ZHANG Jin-ping1, HE Shu-ying2, SONG Wen-fang2(1. Department of Histology and Embryology, School of Medicine, Shaoxing University,Shaoxing 312000, China;2. Counselling Station for Family Planning, Shaoxing 312000, China)
Objective To explore the role of cell proliferation and apoptosis, and the expression significance of involved protein as Bcl-2(B-cell lymphoma/leukemia-2) and Bax (Bcl-associate X protein) in the developing small intestine of human fetus. Methods The expression product of Bcl-2 and Bax was investigated with immunohistochemical methods in the 2nd, 3rd and 4th months of gestation respectively. Results In the second, the third and the fourth month of gestation, the Bcl-2 immunoreactive positive signals were found in the ganglion cells of intermuscular and submucous nerve plexus. Bax positive cells were observed in the cytoplasm of the simple columnar epithelium cells of the small intestinal mucous layer.Conclusion Bcl-2 and Bax proteins regulate the developing small intestine of human fetus.
【CateGory Index】： R321