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Xu Chen,Li Weixin △ (Laboratory of Electron Microscopy,Chongqing University of Medical Sciences,Chongqing)  
The methods of ultrastructural morphometry and thiamine pyrophosphatase(TPPase)cytochemistry as well as the RIA of serum testosterone were performed to investigate the effects of cadmium (Cd)on seminal vesicle in rats.The animals were treated with cadmium chloride(2mg/kg body weight).The results showed that the ultrastructural changes of principal cells were detected after 1 hour of Cd treatment and TPPase reaction product also started to reduce.The degeneration became most prominent within 15 30 days,but tend to alleviate on day 60 after treatment.The main alteration were swelling of mitochondria,dilatation and disruption of Golgi complex, increase of myelin figures and lipid droplets in the cytoplasm.The numerical density on area and volume density of large secretory granules in principal cells were decreased markedly after 15 days; on day 30 the large secretory granules disappeared,however,recovered to some extent on day 60.The reduction of mean diameter of large secretory granules was noted after 3 days which then reduced to about a half of the normal diameter on day 15,but it not returned to normal after 60 days.The serum concentration of testosterone decreased prominently on day 7 and not returned to normal on day 60 after Cd treatment.These results suggested that the early injury of seminal vesicle was related to the direct action of Cd treatment;the decrease of testosterone and the damage of the capillaries might accelerate the degeneration.
【CateGory Index】: R-332
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