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Liao Xiaogang △,Li Weixin (Laboratory of Electron Microscopy,Chongqing University of Medical Sciences,Chongqing)  
The ultrastructural alterations of principal cells and alkaline phosphatase(AlPase) activity of the peritubular tissue as well as the levels of lipid peroxide in epididymal tissue were studied.The rats were divided into several groups at different interval from 10 minutes to 2 months after treatment with small dose of CdCl 2 (2mg/kg body weight).Meanwhile,the protective effects of zinc(Zn) and Vitamin E on cadmium(Cd) induced injury were observed.The results showed that the ultrastructural changes of principal cells were detected after 30 minutes.After 3 7 days,the degenerations of principal cells,peritubular tissue and capillaries became prominent.They appeared to be alleviated after 15 30 days,and tend to recovered after 60 days.AlPase reaction products of peritubular tissue were decreased prominently after Cd treatment.Zn and Vitamin E were able to prevent the injury of cell structure and the inhibition of AlPase activities from Cd.The action of Zn was greater than that of Vitamin E.In addition,this paper confirmed that Cd resulted in a high level of lipid peroxide in epididymides.Vitamin E could be obviously against lipid peroxidation from Cd.
【CateGory Index】: R-332
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