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《ACTA ANATOMICA SINICA》 1999-02
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GOEXISTENCE OF IMMUNE NEURO ENDOCRINE SUBSTANCES IN THE RAT CENTRAL NEURONS

Zhu Changgeng Δ,Liu Qingying,Wei Ying,Ma Chunling, Hao Jiandong, Yan Ping (Department of Anatomy,Tongji Medical University,Wuhan)  
Objective\ To investigate the expression of Interleukin 2(IL 2),metabotropic glutamate receptor subunit 1(mGluR1) and estrogen receptor (ER) in neurons of the rat central nervous system (CNS) and identify the coexistence possibility of these immune neuro endocrine substances in the central neurons.Methods\ The triple labeling immunocytochemical staining technique with different species specific primary antibodies(goat anti IL 2 serum,rabbit anti mGluR1 serum and mouse anti ER serum)were used to incubate two serial neighbor sections(one for demonstrating IL 2,another for mGluR1 and ER) and identify the coexistence of above three kinds of substance in the cerebral cortex,medulla oblongata and spinal cord.Results\ There were IL 2, mGluR1 |and ER immunoreactive(ir)labeled neurons in the above mentioned central areas.The IL 2 ir production showed brown in color,locating in the cytoplasm.In the neighbor serial section,mGluR1 ir production showed blue black in color,locating at the cell membrane;the ER ir production also showed brown color,locating in the cytoplasm or nucleus.There were mGluR1/ER double labeled cells in same section, which accounted for about 50% 60% of the total single and double labeled neurons.It was identified by projection check of serial neighbor sections that there were mGluR1/ER/IL 2 triple labeled cells which accounted for about 30% of total mGluR1/ER double labeled nuurons.Conclusion\ mGluR1,ER and IL 2 can coexist in same rat central neurons,therefore,providing morphological basis for the theory about immune neuro endocrine network at the cellular level for the first time.
【Fund】: 国家自然科学基金
【CateGory Index】: R322.81
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