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《Chinese Journal of Anatomy》 1993-02
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EFFECT OF ANGELICA POLYSAACHARIDE ON GRANULOPOIESIS AND MONOCYTOPOIESIS IN MICE

Wang Yaping;Zhu Bide Chongqing University of Medical Sciences,Chongqing 630046  
By using the techniques of culture of hemopoietic progenilor cell in vitro,we have studied the effect of Angelica Polysaccharid (AP) on granulopoiesis and monocylopoiesis in mice.The results indicate that AP can augment the proliferation of CFU-GM,promote the granulopoiesis and monocytopoiesis in bone marrow,and increase the number of peripheral leukocytes.Our research suggests that AP may enhance the granulopoiesis and monocytopoiesis in mice by activating directly and/or indirectly macrophage and lymphocyte in hemopoietic inductive microenvironment,and by stimulating indirectly skeletal muscle tissue to produce CSF-like activity.This may be one of the mechanisms for the antianemic effect of Angelica Sinensis.
【Fund】: 国家自然科学基金
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