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《Chinese Journal of Anatomy》 2009-02
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Changes of brain-derived neurotrophic factor expressions in the human embryo spinal cord

Li Liyan1,Yang Jinwei1,Guo Jianhui2,Gao Yan1,Zhang Li1,Sun Weiwei1,Gao Wei1,Feng Zhongtang1,Wang Tinghua1(1. Institute of Neuroscience,Kunming Medical College,Kunming 650031;2. Affiliated Kunhua Hospital,Kunming Medical College,Kunming 650032,China)  
Objective:To investigate the expressional changes of brain-derived neurotrophic factor(BDNF)in the human embryonic spinal cord during different development periods.Methods:Immunohistochemistry and Western blot were used to study the localization and quantitation of BDNF protein in the human embryonic spinal cord from the 3rd week to the 8th month.Results:In 15 detected time points,BDNF positive protein was detected in the neural epithelium and ependymal epithelium,and changed regularly as increasing of embryonic age.The results of Western blot demonstrated that the content of BDNF protein was increasing gradually along with the embryonal age from the 6th to the 9th week,reached the peak in the 9th week(P0.05),began to decrease at the 3rd month(P0.05),increased again at 6th month and maintained this level.Conclusion:BDNF may play an important role in the human embryonic spinal cord development especially in the early age and may be involved in the division and growth of the stem cells in neurepithelium.
【Fund】: 云南省自然科学基金(2004C0003R 2007C219M);; 云南省教育厅科研基金(04Z037C)
【CateGory Index】: R321
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