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《Chinese Journal of Anatomy》 2016-05
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Effect of obstructive sleep apnea hypoxia on autophagy of the hippocampal neurons after cerebral ischemia in rats

Guo Xiangfei;Zhao Yaning;Li Jianmin;Chen Changxiang;Li Shuxing;College of Nursing and Rehabilitation,North China University of Science and Technology;Affiliated Hospital,North China University of Science and Technology;  
Objective:To investigate the effects of obstructive sleep apnea hypoxia(OSAH) on autophagy of the hippocampal neurons in rats with ischemia.Methods:Healthy male Wistar rats were randomly divided into sham operation group C SO group),ischemia/reperfusion group(I/R group),OSAH hypoxia for 7 days before ischemia/reperfusion group(IH7 + I/R group) and OSAH hypoxia for 21 days before ischemia/reperfusion group(IH21 + I/R group).Cerebral ischemia-reperfusion animals were prepared by improved Pulsinelli four vessel block(4-VO) for 24 hours.The morphological changes of hippocampal neurons were detected with H-E staining,and the expression of mTOR and beclin-1 in the hippocampus was detected by immunohistochemistry and RT-PCR Results:Compared with the SO group,the I/R group showed damages of hippocampal neurons;immunohistochemistry analysis showed that the number of mTOR and beclin-1 postive cells increased;RT-PCR analysis showed that the expressios of mTOR and beclin-1 were increased.Compared with the I/R group,OSAH hypoxia ischemia groups exacerbated the damage of hippocampal neurons;immunohistochemistry analysis showed that the number of mTOR and beclin-1 postive cells was increased;RT-PCR showed that the expressions of mTOR and beclin-1 were increased at IH7 +I/R group.The above changes were more apparent in the IH21 + I/R group.Conclusion:OSAH hypoxia exacerbates autophagic damages in the hippocampus after ischemia in rats.
【Fund】: 唐山市科技计划项目(14130220B);; 河北省高等学校科学技术研究项目(ZD20131007)
【CateGory Index】: R766;R743
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Chinese Journal Full-text Database 9 Hits
1 WEI Kai-xuan;QI Rong-xiang;SHI Song;CHEN Shi-cai;Department of Otorhinolaryngology Head & Neck Surgery,Changhai Hospital,Second Military Medical University;Department of Traumatic Orthopedics,No.153 Hospital of PLA;;Preoperative diagnosis value of sleep respiration monitoring and upper airway obstruction positioning system for patients with obstructive sleep apnea hypopnea syndrome[J];第二军医大学学报;2015-08
2 DING Huang;TANG Ying-hong;HUANG Xiao-ping;Molecular Pathology Laboratory,Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral Diseases,Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques,Hunan University of Chinese Medicine;Dept of Pharmacology in Pharmacy College,Hunan University of Chinese Medicine;;Effects of autophagy in cerebral ischemic injury[J];中国药理学通报;2015-08
3 ZHANG Wenhui;HE Jun;JI Lei;BIAN Hong;ZUO Li'na;SUN Si;CHEN Yuling;Department of Respiratory, the Affiliated Hospital of Xuzhou Medical College,Jiangsu Province;;Clinical analysis of obstructive sleep apnea syndrome joint with cerebral apoplexy[J];中国医药导报;2014-36
4 WANG Wen-ying;CUI De-rong;JIANG wei;Department of Anesthesiology,the Sixth People's Hospital,Shanghai Jiao Tong University;;Advances of role of autophagy in cerebral ischemia-reperfusion injury[J];上海交通大学学报(医学版);2014-02
5 LIU Sheng-guo,FU Ying-yun,HE Zheng-qiang,et al.Department of Respiratory Medicine,the Second Affiliated Hospital of Jinan University,Shenzhen 518020,China;Relationship between Stroke Risk and Obstructive Sleep Apnea Hypopnea Syndrome[J];中国全科医学;2012-29
6 WANG Zhao1,HUANG Yumeng1,PENG Jun2 (1.Grade 2007,Eight-year System,Xiangya School of Medicine,Central South University,Changsha 410013; 2.Department of Pharmacology,Central South University,Changsha 410078,China);Oxidative stress and cerebral ischemia-reperfusion injury[J];国际病理科学与临床杂志;2012-04
7 WANG Yan-mei,XU En Institute of Neurosciences,the Second Affiliated Hospital of Guangzhou Medical College,Guangzhou 510260, China;Dual roles of autophagy in cerebral ischemia[J];国际脑血管病杂志;2012-03
8 LU Qiao-li,XUE Rong,DONG Li-xia,et al (Department of Neurology,Tianjin Medical University General Hospital,Tianjin 300052,China);Influence of OSAHS on risk factors and cognitive function in patients with ischemic cerebrovascular disease[J];中华老年心脑血管病杂志;2011-04
9 CHEN Xiao-hong1,DENG Li-ying2(1.Department of Neurology,the First Hospital of Nanchang,Nanchang 330008,China;2.Department of Neurology,the Second Affiliated Hospitalof Nanchang University,Nanchang 330006,China);Effect of OSAHS on the Prognosis of Cerebral Infarction[J];江西医学院学报;2008-06
Chinese Journal Full-text Database 7 Hits
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2 FU Chengkai;LI Jianmin;ZHAO Hongtao;LIU Junjie;ZHAO Yaning;LI Xuemei;LIANG Wenji;Experimental Center,Clinical Medical College,North China University of Science and Technology;Department of Neurosurgery,The Affiliated Hospital,North China University of Science and Technology;Community Care Department,School of Nursing and Rehabilitation,North China University of Science and Technology;;Effect of Edaravone on p-ERK1/2 protein and autophagy in the hippocampal neurons of SAH rats[J];新疆医科大学学报;2018-01
3 Zhang Lixiu;Yang Haimiao;Zhu Tonggang;Liu Jimin;Chen Jia;Liu Tong;Affiliated Hospital of Changchun University of Traditional Chinese Medicine;;Influence of "Tiao Zong Qi" prescription on calcium ion concentration in the genioglossus of aged rats with chronic intermittent hypoxia[J];中国社区医师;2017-36
4 SU Li-qing;LIU Jie;ZHANG Yan-hui;HU Hua;YI Ya-qiao;GE Jin-wen;Hunan University of Chinese Medicine;The First Hospital of Hunan University of Chinese Medicine;;Efficacy and safety evaluation of edaravone combined with Danhong Injection in the treatment of acute cerebral infarction rats[J];中华中医药杂志;2017-11
5 ZHANG Huiping;JING Yao;FEI Cailian;Department of Neurology,Shanghai Changzheng Hospital;;Prevention and targeted nursing for sleep apnea-hypopnea syndrome in patients with cerebral apoplexy[J];中西医结合护理(中英文);2017-10
6 CAO Shou-ming;YAN Xin;LI Jian-min;Department of Neurosurgery,Space Center Hospital;Department of Neurosurgery,the Affiliated Hospital of North China University of Science and Technology;;The mechanism of oxygen free radical/JNK signaling pathway on neuronal autophagy after subarachnoid hemorrhage in rats[J];医学研究生学报;2017-09
7 Han Shiqiang;Min Heng;Ren Haijun;Zhang Xinyu;Fu Xuefeng;Department of General Surgery,Jishishan County Hospital;Department of Gastroentenology & Hematology,The 169 Hospital of PLA;Second Affiliated Hospital,Lanzhou University;Department of Carder Ward,Lanzhou General Hospital of PLA;;To compare the protective effects of heat shock protein A5 and 3-methyladenine in mice with cerebral ischemia/reperfusion injury[J];神经解剖学杂志;2017-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WU Bo-yan;LIU Xin-guang;CHEN Wei-chun;Institute of Aging Research,Guangdong Medical College;Guangdong Provincal Key Laboratory of Medical Molecular Diagnostics;Institute of Biochemistry & Molecular Biology,Guangdong Medical College;;Effects of rapamycin induced cellular autophagy in aging-related diseases[J];中国药理学通报;2015-01
2 WANG Yong-bin;WU Jing;SHEN Jing-hao;YANG Xiao-qian;ZHANG Yi-hong;Department of Respiratory Disease,Xiangcheng People's Hospital;;Meta-analysis of relationship between obstructive sleep apnea hypopnea syndrome and metabolic syndrome[J];临床肺科杂志;2014-10
3 HUANG Chun;Department of Neurology,People′s Hospital of Pingxiang City in Jiangxi Province;;Analysis of the correlation between obstructive sleep apnea hypopnea syndrome and cerebral infarction combined with cerebral hemorrhage[J];中国当代医药;2014-24
4 SHI Qiuyan;LIU Bing;ZHANG Chunyang;FAN Yaxia;SUN Yuan;YANG Bin;Department of Neurology,Affiliated Hospital of Hebei United University;;Influences of ischemic preconditioning on autophagy in rats with cerebral ischemia reperfusion injury[J];疑难病杂志;2014-07
5 Wenqi Chen;Yinyi Sun;Kangyong Liu;Xiaojiang Sun;Department of Neurology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University;Zhoupu Hospital;;Autophagy: a double-edged sword for neuronal survival after cerebral ischemia[J];Neural Regeneration Research;2014-12
6 Yin Zeng;Zhang Gaofeng;Chen Huailong;Sun Lixin;Bi Yanlin;Shi Fei;Wang Mingshan;Department of Anesthesiology,Qingdao Municipal Hospital;;Role of AMPK singal pathway in propofol against transient cerebral ischemia/reperfusion injury of aged rats[J];中华临床医师杂志(电子版);2014-10
7 WANG Binhua;YU Mengsun;WU Feng;CAO Zhengtao;YANG Jun;YANG Haiping;College of Control Science and Engineering,Shandong University;Air Force Institute of Aviation Medicine;;Identification and regulation of human hypoxia tolerance based on atmospheric hypoxia chamber[J];北京生物医学工程;2014-01
8 LIAO Cheng-guang,HUANG Qi-liang Department of Internal Medicine Guicheng Hospital in Nanhai District,Foshan,Guangdong 528000,China;Correlation study between obstructive sleep apnea hyperventilation syndrome and patients with cerebral infarction of cerebral hemorrhage[J];临床肺科杂志;2013-09
9 Wei Xianmei1,Zhang Nana1,Yin Min1,Cheng Lei1,Miyazaki S2(1Department of Otolaryngology,the First Affiliated Hospital of NJMU,Nanjing 210029,China;2Department of Sleep Medicine,Shiga University of Medical Science,Otsu 520-2192,Japan);The influence of sleep stage to RR intervals of patients with obstructive sleep apnea syndrome[J];南京医科大学学报(自然科学版);2013-06
10 DING Peiyan,WANG Dong,HE Man,YAN Wenjun Department of Anesthesiology,Gansu Provincial Hospital,Lanzhou730000,China;Short-term fasting induced tolerance against focal cerebral ischemia by autophagy activation in rats[J];中华神经外科疾病研究杂志;2013-03
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