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《Chinese Journal of Interventional Imaging and Therapy》 2006-01
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Efficacy evaluation of percutaneous radiofrequency ablation in combination with transcatheter arterial chemoembolization for large hepatocellular carcinoma

CUI Yan~*, CHANG Jian, ZHOU Li-yan, JI Min, LI Xiao-ou, WANG Ping, DONG Man-ku, ZHNAG Hong-wen, LI Cheng-lin (Department of General Surgery, the 306 Hospital of Chinese PLA, Beijing 100101, China)  
Objective To assess the local treatment efficacy of percutaneous radiofrequency ablation (PRFA) therapy in combination with transcatheter arterial chemoembolization (TACE) for the large hepatocellular carcinoma (HCC). Methods Eighty-one lesions ranged 5.1-15.0 cm in diameter in 76 patients with HCC were treated by PRFA in combination with TACE. RF-2000 generator and 10-needle LeVeen electrode were used percutaneously guided by B-ultrasound. Lesions were destroyed by multiple overlapping thermal ablations encompassing the entire lesion as well as a rim of normal liver tissue (approximately 1.0 cm). TACE was applied pre- and post-PRFA. Patients' survival rate and lesions' necrosis were evaluated. Results The procedures were performed successfully in all patients. Of 76 patients with HCC, the post-PRFA complication rate was 6.58% (5/76), including II°skin burn (2), bile leakage (1), abdominal haemorrhage (1), and acute cholecystitis (1). PRFA-ralated death rate was 1.32% (1/76), and a 75 year-old man died on post-PRFA day 3 due to cerebral infarction. TACE were carried out without any complication. The follow-up rate was 92.1%, with 16~62 months follow-up period (mean, 38 months). The level of serum AFP was declined in 89.3% of the patients. Six cases (8.6%) achieved a complete response (CR), and 63 (90%) achieved a partial response (PR). The effective rate (CR+PR) was 98.6%. The patients' survival rates were 98.6% at 6 months, 72.9% at 1 year, and 30.6% at 3 years, respectively. Conclusion The results of this study suggest that PRFA plus TACE is an effective mini-invasive combined therapy and can be a choice of treatment regime for the large HCC in properly selective patients.
【Fund】: 解放军总装备部医药卫生重点科研课题基金资助(基金编号02ZZY008)
【CateGory Index】: R735.7
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【References】
Chinese Journal Full-text Database 5 Hits
1 ZHAI Bo~(1*) XU Ai-min~2 CHEN Yi~1 LI Xiao-yan~1 LIU Sheng~1 WU Meng-chao~1 1.Department of Ultrasonic Intervention,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China; 2.Department of Radiointervention,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438;Radiofrequency ablation for larger hepatocellular carcinomas[J];Academic Journal of Second Military Medical University;2007-06
2 CUI Yan,ZHOU Li-yan,LIU Zi-pei,JI Min,LI Xiao-ou,DONG Man-ku,WANG Ping,ZHANG Hong-wen,LI Cheng-lin(Department of General Surgery,306 Hospital of PLA,Beijing 100101,China);Management of complications and rehabilitation of 256 hepatic tumors after radiofrequency ablation therapy[J];Acta Academiae Medicinae Militaris Tertiae;2006-18
3 ZHENG Yun-feng,CHEN Ke-min,WANG Zhong-min,GONG Ju,ZHAO Zheng-xin,GU Li-juan.Department of Radiology,Luwan Branch of Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200020,China;Clinical application of CT-guided percutaneous radiofrequency ablation for the treatment of larger hepatocellular carcinomas[J];Journal of Interventional Radiology;2009-05
4 SONG Wei , JIANG Si-feng, LONG Hou-yong, ZHANG Yu-qi Department of Hepatobiliary Surgery, Yanzhou Mining Group General Hospital,(Shandong 273500 , China);Clinical application of transcatheter arterial chemoembolization combined with percutaneous radiofrequency in the treatment of large hepatic tumors[J];Chinese Journal of Current Advances in General Surgery;2008-03
5 BI Ming-jun,LI Qin.Department of Surgery,the Second People's Hospital of Rongcheng,Shandong 264309,China;Effect of Radiofrequency Ablation on Serum MMP-1,-7,-9,-13 in Patients with Hepatocellular Carcinoma[J];Applied Journal of General Practice;2008-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 MU Wei, LI Qiang, ZHANG Lin, CHEN Jie, ZHANG Yong ke, LI Zhong hui (Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Clinical effects of radiofrequency ablation combined with hepatic arterial chemo-embolization for treating hepatocellular carcinoma[J];Acta Academiae Medicinae Militaris Tertiae;2004-14
2 MA Kuansheng, DING Jun, CHEN Min, OU Xia, DONG Jiahong (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Complications of radiofrequency ablation for 549 cases of liver tumor[J];Acta Academiae Medicinae Militaris Tertiae;2005-19
3 CUI Shu-zhong, LIU Hai-ying, TANG Yun-qiang, HU Wei-min, WANG Jia-kang, LI Jian-chang, SONG Tao, LIN Sheng-qu Guangzhou Tumor Hospital and Clinical Center for Cancer Research of Guangzhou Medical College, Guangzhou 510095, China;Radiofrequency thermal ablation combined with arterial embolization for primary liver cancer[J];Journal of First Military Medical University;2003-10
4 Zhu Yining,Yan Wan,Pang Zhidong,et al. Department of General Surgery,Frist People's Hospital,Gangxi,Yulin.Yulin,537000;A CLINICAL RESEARCH INTO RADIOFREQUENCY ABLATION IN TREATING LIVER CANCER THROUGH PERCUTANEOUS LIVER CENTESIS[J];Journal of Hepatobiliary Surgery;2002-03
5 ZHU Yi-ning. Department of General Surgery, the First People's Hospital of Yulin, Yulin 537000;Study of unresectable hepatocarcinoma by transcatheter hepatic artery chemoembolization combined with percutaneous radiofrequency ablation[J];Journal of Hepatopancreatobiliary Surgery;2005-02
6 WU Yu-xuan, DOU Yong-chong, ZHANG Yan-fang, KONG Jian, XU Jian-min. Department of Interventional Radiology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China;Percutaneous radiofrequency ablation for huge liver cancer[J];Journal of Interventional Radiology;2007-11
7 Yan Yong, Cai Zhonghong, Wang Yu, Tian Fuzhou, Chen Tao. Department of General Surgery, Chengdu General Hospital of PLA,Chengdu 610083;Multielectrode radio frequency on advanced liver[J];Digestive Surgery;2003-05
8 Ma Kuansheng, Chen Min, Ding Jun, Wang Shuguang, Bie Ping, Dong Jiahong. Insitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;Radiofrequency ablation in the treatment of liver tumor: report of 315 cases[J];Digestive Surgery;2005-05
9 Li Xiru, Ma Qingjiu, Wu Jinsheng, et al.Department of General Surgery, Tangdu Hospital of the Forth Military Medical University, Xi’an 710038;Percutaneous ultrasound guided radiofrequency ablation therapy for liver tumors.[J];Chinese Journal of Practical Surgery;2000-11
10 CHEN Minhua *, LIU Jibin, YAN Kun, et al. *Department of Ultrasound, Beijing Cancer Hospital of Peking University, Beijing 100036, China;Ultrasound-guided radiofrequency ablation of malignant hepatic tumors[J];Chinese Journal of Uitrasonography;2001-07
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Zhang Liang,Wang Ligang,Fan Weijun,et al.State Key Laboratory of Oncology in Southern China/ Diagnostic Imaging and Intervening Center,Cancer Center,Sun Yat-Sen University,Guangzhou,510060 China;CT-guided percutaneous multipolar radiofrequency ablation for carcinoma of prostate[J];Guangzhou Medical Journal;2009-02
2 ZHU Yu sheng, WU Lin lin,YAN Zhi ping Department of Radiology,Ma An Shan Seventeen Ye Hospital,Ma An Shan 243000, An Hui Sheng, Department of Radiology,Shang Hai Zhong Shan Hospital, Shang Hai, 200032 China;Progresses in Research of Interventional treatment of hepatocellular carcinoma domestic[J];Contemporary Medicine;2009-23
3 ZHOU Wen-bo1,2,YUAN Fang-jun2,SUN Shao-hua2,HU Hong-sheng2,DAI Zong-qing2,ZHNG Qi-chang1 1Department of Hepatobiliary Surgery,Union Hospital of Tongji Medical College,Huazhong Science and Technology University(Wuhan 430022,China) 2Department of General Surgery,Dongfeng Hospital,Yunyang Medical College (Shiyan 442008,China);Investigation of inserting implantable drug delivery system for hepatoma through ileum-portal vein[J];Chinese Journal of Current Advances in General Surgery;2009-09
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