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《Chinese Journal of Interventional Imaging and Therapy》 2006-01
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Efficacy evaluation of percutaneous radiofrequency ablation in combination with transcatheter arterial chemoembolization for large hepatocellular carcinoma

CUI Yan~*, CHANG Jian, ZHOU Li-yan, JI Min, LI Xiao-ou, WANG Ping, DONG Man-ku, ZHNAG Hong-wen, LI Cheng-lin (Department of General Surgery, the 306 Hospital of Chinese PLA, Beijing 100101, China)  
Objective To assess the local treatment efficacy of percutaneous radiofrequency ablation (PRFA) therapy in combination with transcatheter arterial chemoembolization (TACE) for the large hepatocellular carcinoma (HCC). Methods Eighty-one lesions ranged 5.1-15.0 cm in diameter in 76 patients with HCC were treated by PRFA in combination with TACE. RF-2000 generator and 10-needle LeVeen electrode were used percutaneously guided by B-ultrasound. Lesions were destroyed by multiple overlapping thermal ablations encompassing the entire lesion as well as a rim of normal liver tissue (approximately 1.0 cm). TACE was applied pre- and post-PRFA. Patients' survival rate and lesions' necrosis were evaluated. Results The procedures were performed successfully in all patients. Of 76 patients with HCC, the post-PRFA complication rate was 6.58% (5/76), including II°skin burn (2), bile leakage (1), abdominal haemorrhage (1), and acute cholecystitis (1). PRFA-ralated death rate was 1.32% (1/76), and a 75 year-old man died on post-PRFA day 3 due to cerebral infarction. TACE were carried out without any complication. The follow-up rate was 92.1%, with 16~62 months follow-up period (mean, 38 months). The level of serum AFP was declined in 89.3% of the patients. Six cases (8.6%) achieved a complete response (CR), and 63 (90%) achieved a partial response (PR). The effective rate (CR+PR) was 98.6%. The patients' survival rates were 98.6% at 6 months, 72.9% at 1 year, and 30.6% at 3 years, respectively. Conclusion The results of this study suggest that PRFA plus TACE is an effective mini-invasive combined therapy and can be a choice of treatment regime for the large HCC in properly selective patients.
【Fund】: 解放军总装备部医药卫生重点科研课题基金资助(基金编号02ZZY008)
【CateGory Index】: R735.7
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Chinese Journal Full-text Database 5 Hits
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