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《Chinese Journal of Interventional Imaging and Therapy》 2010-04
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Therapeutic effect of transcatheter arterial chemoembolization combined with psychro-circulation percutaneous microwave coagulation therapy for aged patients with hepatocellular carcinoma

WANG Hong-po,YANG Rui-min,LI Yu-xia,CUI Hong-kai,ZHANG Xi-zhong,ZHANG Ming-Qiu(Center of Radiology,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China)  
Objective To evaluate the therapeutic effect of transcatheter arterial chemoembolization(TACE)combined with psychro-circulation percutaneous microwave coagulation therapy(PPMCT)in the treatment of aged patients with hepatocellular carcinoma.Methods Forty-four patients with hepatocellular carcinoma above 60 years old underwent CT-guided PPMCT 1 week after TACE.Digital subtraction angiography(DSA)and enhanced CT were performed after 1 month.The complications during and after operation were observed.The alphafetoprotein(AFP)levels and the diameters of the tumors were measured and compared.The postoperative follow-up period varied from 6 to 18 months.Results No other complications were found except for intraoperative sinus bradycardia occurred in 1 case.One month after the therapy,the primary lesions disappeared completely in 36(81.82%),incomplete necrosis occurred in 6(13.64%)and partial necrosis was found in 2 patients(4.54%).Complete necrosis was found in 12 of 16 metastases.AFP levels decreased in 30 of 32 patients with preoperative abnormal AFP,and in 22 among them decreased to normal range,but increased in the other 2 patients.The survival rate was 100% during the follow-up period,but recurrence and metastasis were found in 8 patients,and 6 of them were found within 12 months after the treatment.Conclusion The sequential TACE-PPMCT is a micro-invasive and safe method with less complications and reliable effect for treatment of primary hepatocellular carcinoma in aged patients.
【Fund】: 河南省教育厅基金(2007320019)
【CateGory Index】: R735.7
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