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《Computer Engineering and Applications》 2007-33
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Study of Ca~(2+) concentrations in cardiac myocytes based on 3-D image processing

ZHANG Sheng-lan,XIE Ming,LUO Dai-sheng,GAN Ke,YU Yan-mei Institute of Image Information, College of Electronic Information, Sichuan University, Chengdu 610064, China  
The spatio-temporal distribution of Ca2+ concentrations in a cardiac myocyte is helpful to get the parameters for circuit modeling of cardiac mycoyte rhythmic motion.A new method for studying the distribution of Ca2+ concentrations in cardiac myocytes was proposed.The sequence images of a cardiac myocyte sampled by Laser Scanning Confocal Microscopy(LSCM) were processed,3-D reconstructed,segmented,and distance transformed to divide the myocardial cell into shells from the membrane toward inside,and the spatio-temporal distribution of the Ca2+ concentration in the cardiac myocyte was got.3-D medical image processing is convenient to biology research and medical diagnosis,and 3-D distance transform method can also be applied to the analogous biomedical researches.
【Fund】: 国家自然科学基金(the National Natural Science Foundation of China under Grant No.30470491)
【CateGory Index】: TP391.41
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