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《Journal of Yangzhou University(Agriculture and Life Sciences Edition)》 2003-02
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MO Hui\|dong (Lab of Quantitative genetics, Yangzhou Univ, Yangzhou, 225009, China)  
The genetic researches of variation for quantitative traits were retrospected since 1885. The researches on quantitative traits lagged that on qualitative traits over long time because of poorly understanding of the genetic basis or architecture for quantitative variation. Since late 1980s, the DNA sequence variants, i.e., the molecular markers, were detected on a large\|scale, and provided densely positional controlls over whole\|genome. Thus, genetic basis researches for quantitative traits were strongly promoted. Up to now, many quantitative traits in 68 species of living things at least, including many important economic traits in plants and animals, and human diseases, have been conducted on the whole\|genome scan for quantitative trait loci (QTL), and QTL mappings were established. However, in generally speaking, a QTL is still a considerable DNA fragment frequently containing multiplex genes. Further investigations on the genetic basis should be deepened: i.e., from QTL to quantitative trait genes (QTG) and from QTG to quantitative trait nucleotides (QTN) corresponding to alleles or paralogs. This is a major challenge for quantitative genetics in the post\|genome era. Extremely abundant molecular polymorphisms such as single nucleotide polymorphisms (SNP) and complete genome sequences in model organisms will greatly advance accurately genetic dissection for quantitative trait variation.
【Fund】: 国家自然科学基金资助项目(30270704)
【CateGory Index】: Q348
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