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《Bulletin of the Academy of Military Medical Sciences》 2009-02
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Characteristics of a rat model of diabetic nephropathy induced by streptozotocin

ZHU Xin-Kai1,2,HUANG Lin-Yi1,HUANG Rui1,2,HAN Chun-Guang1,WANG Qiong1,LIU Yong-Xue1 *(1.Beijing Institute of Radiation Medicine,Beijing 100850,China;2.Jiangxi College of Traditional Chinese Medicine,Nanchang 330004,China)  
Objective:To establish a rat model with diabetic nephropathy(DN) and clarify its characteristics.Methods: Sixty Wistar rats were randomly divided into the control and DN model groups of thirty rats each.The DN model of rats was induced by a single dose of intraperitoneal injection of streptozotocin(STZ) at a dose of 65 mg/kg,and the control rats were injected with an equal volume of citric acid buffer.Clinical and pathological parameters of the rats,including blood glucose,body mass,protein and creatinine of 24-hour urine kidney weight and pathological changes were examined or determined at weeks 6,10,12,16 and 32 after injection.Results:Compared with control rats,persistent hyperglycemia,decreasing body mass and increasing 24-hour urine protein and urine protein/urine creatinine ratio were determined with progression of the disease.In the meantime,pathological examination indicated that the kidney hypertrophy of model rats appeared early,while the changes in glomeruli and renal tubules began to appear at the 10th week,and were gradually aggravated to the stage with the typical lesions of DN in kidneys,including thickening of glomerular mesangium,extracellular matrix hyperplasia and renal tubulo-interstitial damages etc.Conclusion: STZ injection could induce a persistent hyperglycemia in rats,which then could result in the key changes of DN beginning at about 12 weeks after injection.
【Fund】: 北京市自然科学基金资助项目(No.7072058)
【CateGory Index】: R587.1
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Chinese Journal Full-text Database 6 Hits
1 SHI Jing-li1,ZHANG Da-cheng1,HUANG Shu-zhe1,WU Wei-kang2,WU Jin-song3(1The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China;2Institute of Chinese and Western Medicine of Sun Yat-sen University,Guangzhou 510080,China;3Bio-computer Research Center of Shenzhen Graduate School,Harbin Institute of Technology,Shenzhen 518055,China);Study on relationship between the glossoscopy objectivised image and kidey-biopsy pathology type of patients with primary glomerulopathy[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
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6 WANG Kang,LI Ping,ZHANG Haojun,et al Beijing University of Chinese Medicine,Beijing(100029);Study on Developing a Rat Model with Similarity to Late Lesion of Type 2 Diabetic Nephropathy[J];Chinese Journal of Integrated Traditional and Western Nephrology;2010-01
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