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《Military Medical Sciences》 2012-03
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Effects of mustard seed on allergic contact dermatitis in mice

WEN Chun-miao,YANG Run-ping,ZHAO Zi-gang,LIU Dan,ZHAO Hua,LI Heng-jin* (Department of Dermatology,General Hospital of Chinese PLA,Beijing 100853,China)  
Objective To investigate the effect and mechanism of mustard seed on allergic contact dermatitis in BALB/c mice.Methods Thirty BALB/c mice were randomly divided into three groups: mustard seed group,model control group and normal control group,which were respectively given forage added with 5% mustard seed,normal forage,and normal forage for three weeks.Then ACD was induced on the ear skin using 2,4-dinitrofluorobenzene(DNFB).After 24 hours,all the mice were sacrificed.Samples from ears and blood were collected to measure the weight of mice ears and conduct the histopathological and enzyme-linked immunosorbent assay.Results The weight of the mice auricle in mustard seed group was changed less significantly than in the model control group(P0.05).The local infiltration of inflammatory cells was less severe and the level of TNF-α in mustard seed group was lower than in the model control group(P0.05).Conclusion It is demonstrated that mustard seed exerts anti-inflammatory effects to inhibit allergic contact dermatitis induced by 2,4-DNFB in mice by reducing edema of skin,inflammatory infiltration and serum TNF-α.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 2 Hits
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【Co-citations】
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1 WEN Chunmiao1,YANG Runping1,HU Jian1,JIAO Zelong2,YANG Yuguang1,YANG Jianling3,LI Hengjin1,ZHAO Hua1 1Department of Dermatology,General Hospital of PLA,Beijing 100853,China;2Department of Dermatology,Clinic Affiliated to Navy Headquarter,Beijing 100039,China;3Department of Dermatology,513 Hospital of PLA,Lanzhou 732750,China;Effects of mustard seed on 2,4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J];Journal of Southern Medical University;2012-04
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