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《Mycosystema》 2011-04
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Antitumor active constituent in fruiting body of Phellinus yamanoi against Hepatoma H_(22) cell

LIANG Wei BAO Hai-Ying College of Chinese Traditional Medicine,Jilin Agricultural University,Changchun 130118,China  
Three kinds of extracts were made from the fruiting body of Phellinus yamanoi by gradient extraction method using petroleum ether,methanol and water as extracting solution,and 4,6,8(14),22(23)-tetraen-3-one-ergostane was isolated from petroleum ether extract.The anti-tumor activities of the three extracts and the monomer compound against mice Hepatoma H22 were studied in vivo.Inhibition rates of tumor,immune organ indexes and the contents of immune factors were evaluated as indicators.The results showed that the inhibition rates of petroleum ether extract for high dosage group (100mg/kg) and those of monomer compound for middle dosage group (7.5mg/kg) were 62.21% and 57.67%,respectively.Spleen indexes and thymus indexes of petroleum ether extract and monomer compound were higher than those of control group and cyclophosphamide-treated group (CTX) (P0.01),meanwhile inter leukin-2 (IL-2) level of them was obviously higher than that of the control group and cyclophosphamide-treated group (P0.01).Tumor necrosis factor-α (TNF-α) level of petroleum ether extract and monomer compound was significantly lower than that of the control group (P0.01).Hence,the petroleum ether extract and the monomer compound of fruiting body of P.yamanoi inhabit Hepatoma H22 cell of mice,and also can improve mice’s immune function.
【Fund】: 国家自然科学基金(No.30870013)
【CateGory Index】: R285.5
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