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《JIANGXI JOURNAL OF MEDICAL LABORATORY SCIENCES》 2000-01
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Determination of the immunoglobulin and light chains and its clinical significance in patients with Multiple Myeloma

Xu Jiangxia,Liu Ming, Wan Jianxin,Yu Chunshan.Department of Laboratory,Fourth Affiliated Hespital,Jiangxi Medical college,Nanchang 330003  
Objective To study the relation of serum immunoglobin ,κ and λ light chains and the κ:λ ratio to Multiple Myeloma(MM).Methods with rate nephelometry in 28 patients with MM,and 30 normal controls,and calculate the κ:λ ratio.Results Of the 28 patients ,18 had elevated level of κ light chain,10 had elevated level of the λ light chain.Most patients had elevated level of IgG and reduced level of IgA,IgM.14(50%) patients had obviously elevated level of IgG and 4 of IgA and only 2 had elevated level of IgM. 8(28.5%) patients had lower level of IgG、IgA、IgM than normal level.The results indicated that when one light chain was elevated or normal,the other light chain was reduced κelevated abnormally,the κ:λ ratio was 36.25±27.6,when λ was abnormally elevated, the κ:λ ratio was seriously inverted,being 0.16±0.14. Conclusion The diagnosis of Multiple My eloma was suggested when the patients had the unusual level for κ.λ light chain and the κ:λ ratio had chanted obviously.
【CateGory Index】: R730.4
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