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Determination of the immunoglobulin and light chains and its clinical significance in patients with Multiple Myeloma

Xu Jiangxia,Liu Ming, Wan Jianxin,Yu Chunshan.Department of Laboratory,Fourth Affiliated Hespital,Jiangxi Medical college,Nanchang 330003  
Objective To study the relation of serum immunoglobin ,κ and λ light chains and the κ:λ ratio to Multiple Myeloma(MM).Methods with rate nephelometry in 28 patients with MM,and 30 normal controls,and calculate the κ:λ ratio.Results Of the 28 patients ,18 had elevated level of κ light chain,10 had elevated level of the λ light chain.Most patients had elevated level of IgG and reduced level of IgA,IgM.14(50%) patients had obviously elevated level of IgG and 4 of IgA and only 2 had elevated level of IgM. 8(28.5%) patients had lower level of IgG、IgA、IgM than normal level.The results indicated that when one light chain was elevated or normal,the other light chain was reduced κelevated abnormally,the κ:λ ratio was 36.25±27.6,when λ was abnormally elevated, the κ:λ ratio was seriously inverted,being 0.16±0.14. Conclusion The diagnosis of Multiple My eloma was suggested when the patients had the unusual level for κ.λ light chain and the κ:λ ratio had chanted obviously.
【CateGory Index】: R730.4
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Chinese Journal Full-text Database 2 Hits
1 LI Hua,ZHAI Tan.Department of Clinical Laboratory,Donghua Hospital of Zhongshan Medical University,Dongguan,Guangdong 523100,China;Role of serum κ/λ ratio detection in multiple myeloma diagnosis[J];International Journal of Laboratory Medicine;2006-02
2 QIAN Jinxiong, ZHANG Wen, XIAO Yange, CHEN Zuanguang (School of Pharmaceutical Sciences, Sun Yat-sen University, Guangdong, Guangzhou 510006, China);Detection of immunoglobulin——the tumor maker of multiple myeloma[J];Journal of Molecular Diagnostics and Therapy;2009-02
Chinese Journal Full-text Database 9 Hits
1 ZHANG Fu-Miao~① YANG Gui-Wen~① LI GuoTian~① CAO Shan-Dong~② AN Li-Guo~①(①College of Life Sciences, Shandong Normal University, Jinan 250014;②College of Life Sciences, Linyi Teacher′s University, Linyi 276005,China);Isolation, Purification and Partial Characterization of Serum Immunoglobulin in Sea Bass(Lateolabrax japonicus)[J];Chinese Journal of Zoology;2004-05
2 QI Wei-Min;GUO Li(Department of Clinical Laboratories, Tangdu Hospital, Fourth Military Medical University, Xi'an710038);Diagnostic application of quantitation of kappa,lambda light chains and its ratio in patients with multiple myeloma[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-04
3 YANG Zhi-cai,GAO YU-jie,ZHANG Chun-ming,et al.Clinical Laboratory,Affiliated Hospital of Liaoning TCM College,Shenyang 110032,China;Immunology typing of serum protein electrophoresis on multiple myeloma[J];Foreign Medical Sciences;2005-07
4 LIU Wen-yu,MA Jun-long,CHU Gui-xiang,et al.(The General Hospital of Mineral Group of Jixi,Jixi 158100,China);Application of Immunological Detection on Diagnosis of Multiple Myeloma[J];Heilongjiang Medical Journal;2006-11
5 YANG Jun jie 1, ZHANG Guang sen 1, CHEN Xin rui 2, et al (1.Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China 2.Clinical Laboratory, The Second Xiangya Hospital, Central South University, Chan;Analysis of monoclonal protein in 72 cases of multiple myeloma[J];Bulletin of Hunan Medical University;2001-02
6 LIAO Changzheng,YIN Xuenian, XU Ruihuan, et al. Longgang Central Hospital,Shenzhen 518116, China;A study on serum levels of immunoglobulin and complement 3 in pregnancy induced hypertension[J];Experimental and Laboratory Medicine;2008-02
7 Wang Chengfen Huang Dong Chen Duan Duang Yongshou(Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical College, Kunming 650032);Analyzing Assay Result of Serum Immunoglobulin in 24 Patients with Multiple Myloma[J];ACADEMIC JOURNAL OF KUNMING MEDICAL COLLEGE;1998-01
8 LI Fang-fang, FANG Hong-hui, ZHANG Jie, ALAN Solomon, TANG Lian-xiang ( Department of Laboratory Medicine, Shenzhen People's Hospital, Shenzhen 518020; Second Out-Patient Department, Shenzhen People's Hospital, Shenzhen 518020; University of Tennessee Medical Center, 1924 AlcoaHighway, Knoxville TN37920, USA ; Mabsky Biotech Inc, Shenzhen Overseas Chinese Longgang Venture Park II, Shenzhen 518172, China);Clinical Evaluation of Immunoglobulin Free Light Chain ELISA for Early Diagnosis of Multiple Myeloma[J];Journal of Tropical Medicine;2006-01
9 HUANG Ze-yu CHEN Yan(Department of Clinical Laboratory,Capital Medical University,Beijing Tiantan Hospital,Beijing 100050,China);A Case for Multiple Myeloma with Automated Capillary Zone Electrophoresis and Agar Gel Electrphoresis for Analysis of Human Serum Protein[J];Journal of Modern Laboratory Medicine;2007-04
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 MAO Xiao-Bei1,2,CHEN Xie-Qun1,ZHAI Yong-Ping2,LIANG Rong1,GAO Guang-Xun1,MA Guo-Guang2,YU Ya-Ping2,LI Feng21Department of Hematology,Xijing Hospital,The Fourth Military Medical University,Xi′an 710032,Shaanxi Province,China;2Department of Hematology,Nanjing General Hospital of Nanjing Military Area,Nanjing 210002,Jiangsu Province,China;Measurement of Serum Free Light Chains and Its Clinical Significance in 20 Newly Diagnosed Patients of Multiple Myeloma[J];Journal of Experimental Hematology;2008-04
2 Wan Tang,Zhang Min,Gong Jing-lian,Wang Xiao-gang,Huang Guang-ping(The First Hospital of Nanchang City,Nanchang 330008,China);Clinical value of serum albumin electrophorsis for multiple myeloma[J];Chinese Journal of Health Laboratory Technology;2007-10
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