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《Jiangxi Journal of Medical Laboratory Sciences》 2004-01
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Genetic polymorphisms of 6 Y-chromosome specific STR loci in southern Han population of China and its application in paternity testing

DENG Zhihui,LI Dacheng,YU Qiong,et al.Shenzhen Institute of Transfusion Medicine,Shenzhen518035,China  
Objective To study the genetic polymorphisms of six Y-chromosome specific STR loci in the southern Chinese Han population and apply it in forensic science.Methods Six Y-STR loci were amplified by multiple PCR,and the PCR products Y-STR loci were determined in a total of204unrelated males from southern Han population of China.Ninety-three father/son pairs with demonstrated paternity and thirty-eight non-paternity father/son pairs were detected by Y-STR system.Results The number of alleles for DYS393,DYS389 Ⅱ ,DYS390,DYS391and DYS385were5,6,8,6,4and44respectively.A total of177haplotypes at6Y-STR loci were found.Two father/son pairs with single Y-STR mutation were observed in the93father/son pairs with demonstrated paternity.Among the38non-paternity father/son pairs,one case with one ex clusion of paternity,one case with two exclusions and35cases with3or more exclusions were observed.Non-exchusion of paternity at6Y-STR loci was found only in one case.Conclusions The results indicate that the six Y-STR loci are highly polymorphic,and are suitable for personal identification and paternity testing.
【Fund】: 广东省卫生厅科研课题基金资助项目(编号A2001642)
【CateGory Index】: D919
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