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《Chinese Journal of Integrated Traditional and Western Nephrology》 2000-04
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Effect of Astragalus polysacchride on the Mesangial proliferative glomerulonephritis in rat's

LI Zhijun , WEI Lianbo, HE Feng, et alNan Fang hospital, Guangzhou (510515)  
Objective: To explore the effect of Astragalus polysacchride to the rat model of the Mesangial prolif erative glomerulonephritis (MsPGN ) by the change of pathology in rat' s glomerular and the interluekin - 6 in urinary and blood, and to find out the therapeutic mechanism of Astragalus polysacchride. Methods : Imtravenous dadministration of anti - rat thymocyte serum, which reacts with a Thy - 1 - like antigen present on rat glomerular mesangial cells, caused the MsPGN model of SD rat, then feed the Astragalus polysacchride. To observe the change of pathology in rat' s glomerular and measure the interluekin - 6 in urinary and blood. Results: Astragalus polysacchride can reduce the quantity of albuminuria and decrease the quantity of IL - 6 in urinary and blood, can control the hyperplasia of the rat glomerular mesangial matrix, and the manifold of the mesangial matrix, and prevent the deposite of immune complex. Conclusion: 1. Astragalus polysacchride can cure the albuminuria. 2. Astragalus polysacchride can reduce the quantity of the IL-6 in urinary and blood. 3. Astragalus polysacchride can prevent the hyperplasia of the rat glomerular mesangial cells and matrix. 4. Astragalus polysacchride can prevent the hyperplasia of glomerular mesaxon by reduceing the excrete of IL - 6
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 10 Hits
1 YIN You-shengThe Affiliated Hospital of Guilin Medical College, Guilin, 541001, China;Relationship between Interleukin-6 and kidney disease[J];Acta Medicinae Sinica;2004-05
2 ZHU Pijiang,XIE Bing, JIANG Liping Jiangsu Center of Integrated Teaditional and Western Nephropathy, Zhenjiang (212008);The Effect Observation on the Interleukin - 6 of Shenyankang in Rat with Mesangial Proliferative Nephritis[J];Chinese Journal of Integrated Traditional and Western Nephrology;2005-11
3 LIN Ruixia,YANG Qing,CHEN Minguang,et alDepartment of Nephrology,Yuying Children's Hospital,Wenzhou Medical College,Wenzhou(325027);Effect of HQDHT on TH_1/TH_2 in Children's Henoch-Schoenlein Purpura Nephritis[J];Chinese Journal of Integrated Traditional and Western Nephrology;2008-02
4 FANG Xin-sheng1,MU Xiang-shan2,ZHOU Hong-ying1,WANG Jian-hua1,TAN Xiao-mei3(1.Agricultural College in Shandong Agricultural University,Taian 271018,China;2.Key Laboratory of Pharmaceutics of Chinese Materia Medica,Nanfang Medical University,Guangzhou 510515,China;3.Traditional Chinese Medicine Hospital in Taian City,Taian 271000,China);Effect of Astragalosides and Astragalus Polysaccharide on the Proliferation of Glomeruli Mesangial Cells[J];Lishizhen Medicine and Materia Medica Research;2008-06
5 LIN Rui-xia,YANG Qing,CHEN Min-guang,ZHUANG Jie-qiu,CHEN Xiao-ying. Department of Nephrology,Yuying Children's Hospital Affiliated to Wenzhou Medical College,Wenzhou,325027;Therapeutic effect of HQDHT on children with Henoch-Schoenlein purpura nephritis[J];Journal of Wenzhou Medical College;2008-04
6 JIN Tao,WANG Xiaomei,YU Shujing(Department of Internal Medicine,Zaozhuang Municipal Hospital,Zaozhuang,Shandong 277102,China);Effect of astragalus injection on adhesion molecule and C-reactive protein in patients with diabetic cardiomyopathy[J];Acta Academiae Medicinae Xuzhou;2009-01
7 ZHU Pijiang,et al.The Integration of Traditional Chinese and Western Medicine Nephropathy Research Center,Zhenjiang(212023),China;Effect of Shenyankang on MCP-1 of Rats with MsPGN[J];Zhejiang Journal of Integrated Traditional Chinese and Western Medicine;2007-11
8 ZHONG Kai1,WANG Yan-ling1,LIU Yi2,ZOU Si-xiang2,CHEN Wei-hua2(1.Laboratory of Animal Physiology & Biochemistry,Henan Agricultural University,Zhengzhou 450002,China;2.College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China);Establishment of experimental mastitis model by endotoxin in Suining white goat and effect of astragalus polysaccharide on it[J];Chinese Journal of Veterinary Science;2008-07
9 CHEN A-qin, YANG Zhi-gang, YU Song-dong, ZHENG Quan-fang(Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Science,Zhejiang University, Hangzhou, Zhejiang 310029; China);Recent advance in studies on pharmacological activities of Astragalus polysaccharides[J];Chinese Journal of Veterinary Drug;2005-09
10 ZHU Pi-jiang,XIE Bing,JIANG Li-ping.Zhenjiang Nephrologic Institute of Integrated Traditional Chinese and Western Medicine,Zhenjiang 212028,Jiangsu,China;Effect of Shenyankang(肾炎康) on levels of tumor necrosis factor-α and endothelin-1 in rats with mesangial proliferative glomerulonephritis[J];Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care;2006-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 FANG Xiao-song,ZHOU Pin(The First People′s Hospital,Chongqing 400015,China);Clinical efficacy of injection astragalus polysaccharide on treatment primary live cancer patients[J];Chongqing Medicine;2009-08
2 LU Ying-jie1,CHI Shi-hong2,MA Chun-quan1(1.Foshan Scientific Technology College,Nanhai,Guangdong,528231,China;2.Agrotechnique Service Center,Xiongji Town,Zaoyang City,Zaoyang,Hubei,441200,China);Advance in Drug Treatment for Transmissible Gastroenteritis of Swine[J];Progress in Veterinary Medicine;2007-08
3 WANG Nian,MAO Xian-qin,WANG Shen,ZHANG Cheng,ZOU Feng,Ouyang Jing-ping Department of Pathophysiology,School of Medical,Wuhan University,Hubei Allergic and Immune Diseases Related Lab,Wuhan 430071,China;Effects of APS on reducing ER stress and increasing insulin sensitivity in a rat model of type 2 diabetes[J];Journal of Public Health and Preventive Medicine;2007-04
4 Zhang Dezhong,Wen Jianyan,Ji Weifeng Qingtian County People's Hospital,Qingtian,Zhejiang(323900);Changes of Serum Levels of IL-6,TNF-α and CRP in Children with Henoch-Schonlein Purpura[J];Journal of Radioimmunology;2009-03
5 PENG Tao1,LI Wen-ping1,ZHANG Ming-jun1,XIAO Ding-fu2,SU Ding-ding2,WU Yong1,LI Rong-fang1(1.College of Animal Medical,Hunan Agricultural University,Changsha,410128,China;2.College of Animal Science and Technology,Hunan Agricultural University,Changsha,410128,China);Effect of Astragalus Polysaccharide on Physiological and Biochemical Indexes in Exhausted Swimming Mice[J];China Animal Husbandry & Veterinary Medicine;2008-12
6 Department of renal diseases, Qianwei Country Peoples's Hospital, Qianwei 614400, Sichuan WANG Yong-liang;Prednisone Combined with Xuebijing Injection for the Treatment of 36 Cases of Nephrotic Syndrome[J];Journal of Anhui Health Vocational & Technical College;2010-04
7 Guo Cuiping Zhumadian second Chinese Medicine Hospital ,Henan,Zhumadian 463000;Treatment of irritable bowel syndrome by Lipi Decoction for 34 cases[J];Guangming Journal of Chinese Medicine;2010-11
8 LI Xiao-Dong1,LI Juan2,YANG Li-xia1,JIANG Hua1 1 Gansu Province of Chinese Medical Research Institute,Lanzhou Gansu China 730050;2 Gansu Province of People's Hospital;Research Progress on Hypoglycemic Effect of Chinese Herbal Plant Polysaccharide[J];Gansu Journal of Traditional Chinese Medicine;2010-11
9 LIU Wen-dong,YU Ling-xiang,XUE Ai-hong,LI Hong.(Qingdao Municipal Hospital,Qingdao,Shandong 266071,China);Changes and clinical significance of serum TNF-α,IL-4 and IL-6 in the children with henoch-schonlein purpura[J];Chinese Journal of Child Health Care;2011-01
10 JING Zhi-yu1,2,GUO Feng-xia2,CHEN Yuan1,3,XI Zhuo-xia4,YAO Li-rong4,ZHANG Xiao-hu4(1.Gansu Provincial Key Laboratory of Aridland Crop Science,Gansu Agricultural University,Lanzhou 730070,China;2.College of Life Sciences and Technology,Gansu Agricultural University, Lanzhou 730070,China;3.College of Agronomy,Gansu Agricultural University, Lanzhou 730070,China;4.Gansu Fuzheng Pharmaceutical Sciences and Technologies Co.Ltd.,Dingxi 743000,China);Studies on seed filling characteristics of Astragalus membranaceus var.mongholicus[J];Acta Prataculturae Sinica;2011-01
China Proceedings of conference Full-text Database 1 Hits
1 ;Clinical observation on treating primary liver cancer with Jian-pi Qing-gan compound plus TACE[A];[C];2007
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