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《Chinese Journal of Integrated Traditional and Western Nephrology》 2000-04
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Effect of Astragalus polysacchride on the Mesangial proliferative glomerulonephritis in rat's

LI Zhijun , WEI Lianbo, HE Feng, et alNan Fang hospital, Guangzhou (510515)  
Objective: To explore the effect of Astragalus polysacchride to the rat model of the Mesangial prolif erative glomerulonephritis (MsPGN ) by the change of pathology in rat' s glomerular and the interluekin - 6 in urinary and blood, and to find out the therapeutic mechanism of Astragalus polysacchride. Methods : Imtravenous dadministration of anti - rat thymocyte serum, which reacts with a Thy - 1 - like antigen present on rat glomerular mesangial cells, caused the MsPGN model of SD rat, then feed the Astragalus polysacchride. To observe the change of pathology in rat' s glomerular and measure the interluekin - 6 in urinary and blood. Results: Astragalus polysacchride can reduce the quantity of albuminuria and decrease the quantity of IL - 6 in urinary and blood, can control the hyperplasia of the rat glomerular mesangial matrix, and the manifold of the mesangial matrix, and prevent the deposite of immune complex. Conclusion: 1. Astragalus polysacchride can cure the albuminuria. 2. Astragalus polysacchride can reduce the quantity of the IL-6 in urinary and blood. 3. Astragalus polysacchride can prevent the hyperplasia of the rat glomerular mesangial cells and matrix. 4. Astragalus polysacchride can prevent the hyperplasia of glomerular mesaxon by reduceing the excrete of IL - 6
【CateGory Index】: R285.5
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