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《Chinese Journal of Integrated Traditional and Western Nephrology》 2001-07
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Comparison of estimated glomerular filtration rate usingfractional uptake of~(99m) Tc-DTPA and creatinine clearancecalculated by traditinal methods

LIANG Bo, MAI Ciguang, ZHANG Jinshan Affiliated Guangzhou Second People's Hospital of Guangzhou Medical College, Guangzhou Medical College, Guangzhou(510150)  
Objective:To assess the validity of estimated glomerular filtration rate (GFR) using creatinine clearance (Ccr) in Chinese with chronic renal disease, and to introduce a new calculating equation derived by ToTo and his colleagues (ToToes' equation) for estimated Ccr from serum creatinine (Scr).Methods: Ccr was calculated according to Scr by three methods:creatinine clearance from 24-h urine collection(24 hCcr),Cockcroft-Gault equation (Ccr-CG) and ToToes' equation (Ccr-TT),and were compared with GFR measured by fractional uptake of 99m Tc-DTPA (Gates' method) in 100 Chinese with chronic renal disases (50 men, 50 women). Accuracy was assessed by the mean difference of GFR -Ccr (△GFR) and the mean ratio of Ccr/GFR (GFR-ratio). Precision was estimated from the coefficient of determination (r 2) and the combined root mean squared error (CRMSE). Results: In male: (1)△GFR:Ccr-CG≈CCR-T24 hCcr;(2)GFR ratio:Ccr-CG≈Ccr-TT24 hCcr;(3)r 2:Ccr-CGCcr-TT24 hCcr;(4)CRMSE:Ccr-CG≈Ccr-TT24 hCcr.In female:(1)△GFR:Ccr-TTCcr-CG24 hCcr;(2)GFR ratio:Ccr-TTCcr-CG24 hCcr;(3)r 2:Ccr-CGCcr-CG≈24 hCcr;(4)CRMSE:Ccr-TTCcr-CG24 hCcr.Conclusion: To estimated GFR ,the accuracy and reliability of ToToes' equation is superior to those of Cockcroft-Gault equation for women and is simillar for men in this Chinese population.GFR calculated from 24 h Ccr is less accurate compared to other methods.
【CateGory Index】: R690.4
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