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《Chinese Journal of Integrated Traditional and Western Nephrology》 2002-03
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Effect of Radix Astragali on sFasL and T Cell Subsets in Patients with Uremia

JIN Jiansheng,ZHENG Xiangxiong,LIN Qingyou,et al Department of nephrology,Union Hospital,Fujian Medical University,Fuzhou (350001)  
Objective:To investigate the possible mechanisms of radix astragali in improving renal function in uremic patients. Methods: 20 normal volunteers were selected as controls and 25 patients were enrolled in the study. Plasma sFasL was tested by ELISA and T cell subset was tested by flow cytometry. Renal function was also analyzed. Results: Compared to normal controls, plasma sFasL level was elevated and the percentage of CD 3 +CD 4 + subset decreased significantly. The percentage of CD 8 + subset increased and the ratio of CD 4 +/CD 8 + was less than 1(P0.01). sFasL decreased and the ratio of CD 4 +/CD 8 + increased after astragali treatment (P0.05). Serum creatinine and urea nitrogen also decreased(P0.05). Plasma creatinine and urea nitrogen during the period of the treatment was positively correlated with plasma sFasL. Conclusion: Improving cellular immune function and modifying apoptosis may be the mechanisms of radix astragali in improving renal function for uremic patients.
【Fund】: 福建省教委基金资助项目 (No .K980 32 )
【CateGory Index】: R692.5
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