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《Chinese Journal of Integrated Traditional and Western Nephrology》 2003-10
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Renal Protection of Mongelian Milkvetch Root on Radiocontrast Acute Renal Failure in Diabetic Rats

LIU Yi,LIN Fan,ZHENG Chenfei,et al The First Affiliated Hospital, Wenzhou Medical College,Wenzhou (325000)  
Objective:To study the renal protection of mongelian milkvetch root on radiocontrast acute renal failure in diabetic rats.Methods:Streptotocin-induded diabetic rats were randomly assigned into 3 groups: diabetic rats(n=6), diabetic rats injected with diatrizoate(10 ml/kg,n=6) and diabetic rats treated with mongelian milkvetch root(1 g/250 mg,n=10)before diatrizoate injection(10 ml/kg). Renal function and plasma endothelin-1 was measured before and after injection. The protein expression of ET-1,ETR-A and ETR-B was determined by immuno-histochemistry.Results:In the diabetic rats treated with mongelian milkvetch root,reduction of glomerular filtration rate(GFR)was less than those without mongelian milkvetch root treatment before diatrizoate injection. There was no significant difference in plasma ET-1 concentration between two groups, but it was lower than that of normal rats. Immunochemistry analysis showed reduced expression of ET-1,ETR-A and ETR-B in the rats treated with mongelian milkvetch root.Conclusion:Mongelian milkvetch root has renal protection on acute renal failure in diabetic rats induced by contrast media, probably due to suppression of renal local endothelin system.
【Fund】: 浙江省卫生厅基金资助项目 (No .2 0 0 0A0 3 1)
【CateGory Index】: R285.5
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