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《Chinese Journal of Integrated Traditional and Western Nephrology》 2003-12
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Protective Effect of Erzi Mixture on Kidney of Diabeic Rats

LOU Jihua,LI Yayu, CUI Xingcheng,et al Department of Kidney, Hangzhou Hospital of TCM,Hangzhou (310007)  
Objective:To investigate the function of treatment with Fructus Arctii and Fructus Schisandrae (AS) on diabetic nephropathy.Methods:Diabetic rats were induced by streptozotocin (STZ). They were randomly divided into 5 groups: normal control group, diabetic group including untreated group, Fosinopril sodium-treated group, AS-treated group with large dosage, AS-treated group with small dosage. Blood glucose, urine volumn, urine protein volumn and urine albumin volumn of 24 hours, blood TCH, urine ET-1、TNF-2 and renal biopsy pathology were determineated after 4 weeks.Results:In the group and AS (Large dosage) group all of the tests showed improvement. Their curative effects were similar. But AS (small dosage) only showed the decrease of the urine albumin volumn and the surface density of glomerular capillary. Conclusion:The function of treatment with the mixture of Fructus Arctii and Fructus schisandrae on diabetic nephropathy may be achieved. This function could be increased with the increase of dosage.
【Fund】: 杭州市卫生局科研基金资助项目 (No .9713 )
【CateGory Index】: R285.5
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