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《Chinese Journal of Integrated Traditional and Western Nephrology》 2004-02
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Experimental Study on Tetramethylpyrazines in Preventing Ischemic Acute Renal Failure

PAN Long,LI Xiaohui,CAO Caixia,et alDepartment of Nephrology, Affiliated Hospital of Shangxi College ofTradtional Chinese Medicine,Xi an (712083)  
Objective:To study the protective effects and mechanism of tetramethylpyrazines(TMP) in ischemic acute renal failure(IARF).Methods:Ischemic acute renal failure model was established by bilateral clipping of renal arteries for 45min and reperfusion for 24 hours. Rats were assigned into sham, model and TMP-treated groups. Serum creatinine(Scr), blood urea nitrogen(BUN), nitrogen monoxide(NO), endothelin(ET) and renal pathology were analyzed. Results:Scr, BUN and ET were significantly lower in TMP-treated group than those of model group(P0.05) while NO was significantly higher in TMP-treated group than that of model group(P0.05).Conclusion:The protective effects TMP in reducing renal lesions induced by IARF may be associated with regulation of ET secretion and serum NO concentration.
【Fund】: 陕西省教育厅基金资助项目 (No .0 2JK188)
【CateGory Index】: R285.5
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