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《Chinese Journal of Integrated Traditional and Western Nephrology》 2004-07
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The Protein Expression of PDGF-β and TNF-α in the Pathogenesis of Mesangial Proliferative Glomerulonephritis

ZHANG Weidong,LIU Yuqing,JIANG Hongxin,et al Department of Pathology of Weifang Medical College, Weifang (261042)  
Objective:To study the protein expression of the PDGF-β and TNF-α in the pathogenesis of the human mesangial proliferative glomerulonephritis.Methods:Histopathological analysis (HE, PAS, PASM), electromicroscope and immunohistochemistry were used to evaluate the change and expression of PDGF-β and TNF-α in the tissues of kidney.Results:The protein expression of PDGF-β and TNF-α in glumeruli and renal tubles were much higher than control group(P0.05).Conclusion:Increased expression of PDGF-β and TNF-α protein may play an important role in the proliferation of glumeruli mesangial cells and renal interstitial fibrosis in mesangial proliferative glomerulonephritis.
【Fund】: 山东省卫生厅科研基金资助项目 (No .970 12 )
【CateGory Index】: R692.3
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