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《Chinese Journal of Integrated Traditional and Western Nephrology》 2005-04
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The Study on Adriamycin-induced Glomerulosclerosis Rats Model

ZHANG Lifen,HUANG Wenzheng,ZHU Xiaodi,et alDepartment of Nephrology Endocrinopathy,Dongzhimen Hospital of Beijing Chinese Medicine University,Beijing (100700)  
Objective:To study glomerulosclerosis rats modeling in different development pathologic stages.Methods:Glomerulosclerosis rats model were induce by unilateral nephrectomy and injecting different doses adriamycin,and observed the blood and urine biochemistry examinations and renal pathologic changes.Results:24 hour urine protein excretion,blood lipid,blood urea nitrogen and serum creatinine in the experimental rats increased at the end of 8weeks;Lightscope and electronlicroscopy showed the fragment segmental glomerulosclerosis of model rats induced by bigger doses adriamycin injection was distributing diffusely above 80 percent, about 25%~50%glomeruli showed mostly scleroses. Glomerulus viscera epithelia cells were effacement of foot processes; tubule epithelia cells were dilatation or atrophy, lots of albumen tubule type, interstitialfibrosis, lymphocyte and monocyte soakage;Lower doses adriamycin injection rats show localized glomerulosclerosis, obesity glomerulus,and overspread bowman's scapsule,about 50 percent glomeruli suffering different degree sclerosis, 10 percent were mostly scleroses, interstitalfibrosis and localized ymphocyte and monocyte soakage.Conclusion:Adriamycin made obviously damnification to glomerulus's visceral epithelial cells, endothelial cells and tubule epithelial cells;Both two glomerulosclerosis rats model were successful made; while the bigger doses injection rats expressed as metaphase or terminal pathology glomerulosclerosis changes,the lower doses expressed as forepart glomerulosclerosis changes.
【Fund】: 天津市自然科学基金资助项目 (No .0 2 3 6115 11)
【CateGory Index】: R-332
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