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《Chinese Journal of Integrated Traditional and Western Nephrology》 2005-07
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Effect of Gypenosides on Expression of Connective Tissue Growth Factor(CTGF) in UUO Rats with Renal Tubulointerstitial Fibrosis

ZHANG Yong,DING Guohua,ZHANG Jiane,et alDivision of Nephrology,The Affiliated Renmin Hospital of Wuhan University,Wuhan (430060)  
Objective:To investigate the expression CTGF in rats with renal tubulointerstitial fibrosis and the effects of Gypenosides treatment on CTGF protein production.Methods:Rat unilateral ureteral obstruction(UUO) model was used for the study. The expression of CTGF,TGF-β_1,α-SMA in the obstructed kidneys was assessed by RT-PCR,immunohistochemistry and HE staining after 9 days. At the same time,the degree of tubulointerstitial damage was scored by Masson staining. Results:The levels of CTGF,TGF-β_1 and α-SMA in the UUO group significantly increased compared to the sham-operated group(P0.01)and paralleled with the degree of tubulointerstitial damage. In comparison with the model group, the levels of CTGF and expression of TGF-β_1,α-SMA were significantly reduced by Gypenosides treatment. The protein level of CTGF had positive correlation with the index of TGF-β_1(r=0.879,P0.01),α-SMA (r=0.940,P 0.01) and tubulointerstitial damage(r=0.756,P0.01).Conclusion:Gypenosides can suppress development of fibrosis, at least in part via down-regulating CTGF expression.
【Fund】: 湖北省教育厅科研基金资助项目(No.D200524006)
【CateGory Index】: R285
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